Journal Article

Recent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosis

Zhao, Meiru, Li, Min, Song, Siyu, Yin, Kai, Wang, Zeyu, Ding, Lu, Li, Xueyan, Hou, Juan, Li, Xiangyan, Chen, Tian

2024

Overview

Respiratory diseases, marked by structural changes in the airways and lung tissues, can lead to reduced respiratory function and, in severe cases, respiratory failure. The side effects of current treatments, such as hormone therapy, drugs, and radiotherapy, highlight the need for new therapeutic strategies. Traditional Chinese Medicine (TCM) offers a promising alternative, leveraging its ability to target multiple pathways and mechanisms. Active compounds from Chinese herbs and other natural sources exhibit anti-inflammatory, antioxidant, antitumor, and immunomodulatory effects, making them valuable in preventing and treating respiratory conditions. Ferroptosis, a unique form of programmed cell death (PCD) distinct from apoptosis, necrosis, and others, has emerged as a key area of interest. However, comprehensive reviews on how natural products influence ferroptosis in respiratory diseases are lacking. This review will explore the therapeutic potential and mechanisms of natural products from TCM in modulating ferroptosis for respiratory diseases like acute lung injury (ALI), asthma, pulmonary fibrosis (PF), chronic obstructive pulmonary disease (COPD), lung ischemia–reperfusion injury (LIRI), pulmonary hypertension (PH), and lung cancer, aiming to provide new insights for research and clinical application in TCM for respiratory health.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Acupuncture / Acute respiratory distress syndrome / Amino acids / Antioxidants / Antitumor activity / Apoptosis / Asthma / Autophagy / B cells / Cell death / Chronic obstructive pulmonary disease / Complementary & Alternative Medicine / Fatalities / Fatty acids / Ferroptosis / Fibrosis / Genes / Health aspects / Homeostasis / Immunomodulation / Infections / Inflammation / Iron / Ischemia / Lipid peroxidation / Lipids / Lung cancer / Lung diseases / Mechanism / Medicine / Medicine & Public Health / Medicine, Botanic / Medicine, Chinese / Medicine, Herbal / Metabolism / Metabolites / Natural products / Oxidative stress / Proteins / Pulmonary hypertension / Radiation therapy / Reperfusion / Respiratory agents / Respiratory diseases / Respiratory function / Review / TCM / Traditional Chinese Medicine