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Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments

by SAIKI, IKUO , NAKAYAMA, TAKASHI , SAKURAI, HIROAKI , KOIZUMI, KEIICHI , YOSHIE, OSAMU , MIYAZONO, TAKAYOSHI , SUGIYAMA, TOSHIRO , MURAKAMI, JUN , WADA, AKINORI , IITSUKA, HIROFUMI , ITO, AYA , SHIBAHARA, NAOTOSHI , TSUNEYAMA, KOICHI

in adhesion / Angiogenesis / Arthritis / Bone marrow / Bone Neoplasms - genetics / Bone Neoplasms - pathology / Bone Neoplasms - secondary / Care and treatment / Cell adhesion & migration / Cell Adhesion - genetics / Cell cycle / Cell Differentiation - genetics / Cell Line, Tumor / chemokine CX3CL1 / Chemokine CX3CL1 - biosynthesis / Chemokine CX3CL1 - genetics / Chemokines / CX3C Chemokine Receptor 1 / Cytokines / Development and progression / Disease / Gene expression / Gene Expression Regulation, Neoplastic / Genetic aspects / Health aspects / Hematology / Humans / Ligands / Lymphocytes / Lymphoma / Multiple myeloma / Multiple Myeloma - genetics / Multiple Myeloma - pathology / osteoclast / Osteoclasts - metabolism / Osteoclasts - pathology / Phosphorylation / Plasma / Receptors, Chemokine - biosynthesis / Receptors, Chemokine - genetics / Signal Transduction / Studies / survival pathway / Tumor Microenvironment - genetics / Tumors / Vascular Cell Adhesion Molecule-1 - genetics

2015

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Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments

2015

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Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments

2015

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Journal Article

Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments

SAIKI, IKUO,

NAKAYAMA, TAKASHI,

SAKURAI, HIROAKI,

KOIZUMI, KEIICHI,

YOSHIE, OSAMU,

MIYAZONO, TAKAYOSHI,

SUGIYAMA, TOSHIRO,

MURAKAMI, JUN,

WADA, AKINORI,

IITSUKA, HIROFUMI,

ITO, AYA,

SHIBAHARA, NAOTOSHI,

TSUNEYAMA, KOICHI

2015

Overview

Several chemokines/chemokine receptors such as CXCL12, CCL3, CXCR4 and CCR1 attract multiple myelomas to specific microenvironments. In the present study, we investigated whether the CX3CL1/CX3CR1 axis is involved in the interaction of the multiple myeloma cells with their microenvironment. The expression of CX3CR1 (also known as fractalkine) was detected in three of the seven human myeloma cell lines. CX3CL1-induced phosphorylation of Akt and ERK1/2 was detected in the CX3CR1-positive cell lines, but not in the CX3CR1-negative cell lines. In addition, CX3CL1-induced cell adhesion to fibronectin and vascular cell adhesion molecule-1 (VCAM-1) in the human myeloma RPMI-8226 cell line. We also investigated whether a relationship existed between myeloma cells and osteoclasts that may function via the CX3CL1/CX3CR1 axis. Conditioned medium from CX3CL1-stimulated RPMI-8226 cells drastically increased the osteoclast differentiation. Collectively, the results from the present study support the concept of the CX3CL1-mediated activation of the progression of the multiple myeloma via CX3CR1. Thus, CX3CR1 may represent a potential therapeutic target for the treatment of multiple myeloma in a bone microenvironment.

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Publisher

D.A. Spandidos,Spandidos Publications,Spandidos Publications UK Ltd

Subject

/ Bone Neoplasms - genetics

/ Bone Neoplasms - pathology

/ Bone Neoplasms - secondary