Journal Article

Role of cell adhesion molecules in acute ischemic stroke

Kes, Vanja Basic, Supanc, Visnja, Demarin, Vida, Biloglav, Zrinka

2011

Overview

The expression of soluble adhesion molecules inter-cellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), besides activation of endothelial cells and transendothelial migration of leukocytes, play an important role in inflammation and progression of ischemic injury after acute stroke. The aim of this study was to determine serum levels of soluble ICAM-1 and VCAM-1 in patients with acute ischemic stroke and controls and correlate them according to etiological subtypes (thromboembolic or lacunar stroke), stroke severity and disability after acute stroke. Hospital-based prospective study of acute stroke patients hospitalized between December 2008 and September 2009 at the University Hospital Sestre Milosrdnice in Zagreb, Croatia. We enrolled 110 patients with acute ischemic stroke and 93 healthy individuals as controls. Serum concentrations of VCAM-1 and ICAM-1 were determined by means of quantitative sandwich enzyme immunoassay. Patients were classified according to etiological subtype, clinical severity of stroke and disability after stroke. There was no significant difference between levels of soluble adhesion molecules VCAM-1 and ICAM-1 in patients and in controls. Levels of VCAM-1 were significantly higher in patients with thromboembolic stroke than in controls. There was no significant correlation between levels of soluble adhesion molecules VCAM-1 and ICAM-1 and stroke severity and disability. There was marked biological interindividual variability in all patient groups. This study confirms the role of adhesion molecule VCAM-1 in the pathogenesis of acute thromboembolic stroke.

• Publisher: Medknow Publications and Media Pvt. Ltd,KING FAISAL SPECIALIST HOSPITAL & RESEARCH CENTRE,Medknow Publications,King Faisal Specialist Hospital and Research Centre
• Subject: Adult / Aged / Aged, 80 and over / Brain damage / Brain Ischemia - blood / Brain Ischemia - pathology / Case-Control Studies / Cell adhesion molecules / Clinical medicine / Croatia / Development and progression / Diabetes / Disability Evaluation / Disease / Drug therapy / Female / Hospitals, University / Humans / Immunoenzyme Techniques / Intercellular Adhesion Molecule-1 - blood / Male / Middle Aged / Original / Physiological aspects / Prospective Studies / Risk factors / Severity of Illness Index / Stroke / Stroke (Disease) / Stroke - blood / Stroke - pathology / Studies / Thromboembolism / Thromboembolism - pathology / Vascular Cell Adhesion Molecule-1 - blood