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Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease
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Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease
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Journal Article
Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease
2021
Overview
Autism spectrum disorder (ASD) is a multifactorial disorder with characteristic synaptic and gene expression changes. Early intervention during childhood is thought to benefit prognosis. Here, we examined the changes in cortical synaptogenesis, synaptic function, and gene expression from birth to the juvenile stage in a marmoset model of ASD induced by valproic acid (VPA) treatment. Early postnatally, synaptogenesis was reduced in this model, while juvenile-age VPA-treated marmosets showed increased synaptogenesis, similar to observations in human tissue. During infancy, synaptic plasticity transiently increased and was associated with altered vocalization. Synaptogenesis-related genes were downregulated early postnatally. At three months of age, the differentially expressed genes were associated with circuit remodeling, similar to the expression changes observed in humans. In summary, we provide a functional and molecular characterization of a non-human primate model of ASD, highlighting its similarity to features observed in human ASD.
Non-human primate models of autism spectrum disorder (ASD) are few and not well characterised. Here, the authors describe synaptic function and gene expression changes in a marmoset model of ASD from birth to juvenile, highlighting its similarity to features observed in human ASD.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/28
/ 45/61
/ 9/30
/ 9/74
/ Animals
/ Autism
/ Autism Spectrum Disorder - chemically induced
/ Autism Spectrum Disorder - genetics
/ Autism Spectrum Disorder - physiopathology
/ Birth
/ Children
/ Circuits
/ Dendritic Spines - physiology
/ Evoked Potentials - physiology
/ Gene Expression Profiling - methods
/ Genes
/ Humanities and Social Sciences
/ Humans
/ Neuronal Plasticity - genetics
/ Neuronal Plasticity - physiology
/ Oligonucleotide Array Sequence Analysis - methods
/ Patch-Clamp Techniques - methods
/ Prefrontal Cortex - cytology
/ Prefrontal Cortex - metabolism
/ Prefrontal Cortex - physiology
/ Primates
/ Science
