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Generation of pluripotent stem cells from patients with type 1 diabetes
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Generation of pluripotent stem cells from patients with type 1 diabetes
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Journal Article
Generation of pluripotent stem cells from patients with type 1 diabetes
2009
Overview
Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic β cells. The cellular and molecular defects that cause the disease remain unknown. Pluripotent cells generated from patients with T1D would be useful for disease modeling. We show here that induced pluripotent stem (iPS) cells can be generated from patients with T1D by reprogramming their adult fibroblasts with three transcription factors (OCT4, SOX2, KLF4). T1D-specific iPS cells, termed DiPS cells, have the hallmarks of pluripotency and can be differentiated into insulin-producing cells. These results are a step toward using DiPS cells in T1D disease modeling, as well as for cell replacement therapy.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Adult Stem Cells - metabolism
/ Adult Stem Cells - pathology
/ Adult Stem Cells - transplantation
/ adults
/ Diabetes
/ Diabetes Mellitus, Type 1 - metabolism
/ Diabetes Mellitus, Type 1 - pathology
/ Diabetes Mellitus, Type 1 - therapy
/ Humans
/ Induced pluripotent stem cells
/ insulin-dependent diabetes mellitus
/ Male
/ patients
/ Pluripotent Stem Cells - metabolism
/ Pluripotent Stem Cells - pathology
