Asset Details
Do you wish to reserve the book?
Glial Cell Line-Derived Neurotrophic Factor Promotes the Survival and Morphologic Differentiation of Purkinje Cells
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Glial Cell Line-Derived Neurotrophic Factor Promotes the Survival and Morphologic Differentiation of Purkinje Cells
Do you wish to request the book?
Glial Cell Line-Derived Neurotrophic Factor Promotes the Survival and Morphologic Differentiation of Purkinje Cells
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Glial Cell Line-Derived Neurotrophic Factor Promotes the Survival and Morphologic Differentiation of Purkinje Cells
1995
Overview
Glial cell line-derived neurotrophic factor (GDNF) promotes survival of midbrain dopaminergic neurons and motoneurons. Expression of GDNF mRNA in cerebellum raises the possibility that cells within this structure might also respond to GDNF. To examine potential trophic activities of GDNF, dissociated cultures of gestational day 18 rat cerebellum were grown for ≤21 days in the presence of factor. GDNF increased Purkinje cell number without affecting the overall number of neurons or glial cells. A maximal response (50% above control) was elicited with GDNF at 1 pg/ml. Effects of GDNF on Purkinje cell differentiation were examined by scoring the morphologic maturation of cells in treated and control cultures. GDNF increased the proportion of Purkinje cells that displayed relatively mature morphologies, characterized by dendritic thickening and the development of spines and filopodial extensions. Morphologic maturation of the overall neuronal population was unaffected. In sum, our data indicate that GDNF is a potent survival and differentiation factor for Purkinje cells, the efferent neurons of cerebellar cortex. Together with its other actions, these findings raise the possibility that GDNF might be a critical trophic factor at multiple loci in neuronal circuits that control motor function.
Publisher
National Academy of Sciences of the United States of America,National Acad Sciences,National Academy of Sciences
Subject
/ Cell Differentiation - drug effects
/ Cell Survival - drug effects
/ Glial Cell Line-Derived Neurotrophic Factor
/ Glial Fibrillary Acidic Protein - analysis
/ Humans
/ Kinetics
/ Nerve Growth Factors - pharmacology
/ Nerve Tissue Proteins - analysis
/ Nerve Tissue Proteins - pharmacology
/ Neurons
/ Phosphopyruvate Hydratase - analysis
/ Purkinje Cells - drug effects
/ Rats
