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Hypertension in post-renal transplant patients : pilot study
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Journal Article
Hypertension in post-renal transplant patients : pilot study
2014
Overview
Post-transplant hypertension is a major risk factor for graft loss and patient survival;
therefore, hypertension following renal transplantation must be treated strictly. There seems
to be a strong association between hypertension, total body water (TBW) and dry weight. In this
study, we report the relationship of body water and body composition with hypertension in postrenal
transplant patients. Forty-five post-transplant patients were enrolled in the study. Blood
pressure (BP) was labeled as controlled if BP was 120/80 mm Hg and not under good control if
BP was above 120/80 mm Hg. Based on the number of antihypertensive medications a patient
was taking, patients were divided into two groups: Group 1 patients on one antihypertensive drug
and Group 2 patients on more than one antihypertensive drug. Nutritional status of the patients
was assessed. Body composition (water compartments, body fat and lean mass) was assessed
using bioelectrical impedance analysis (BIA). Patient data were compared with 30 healthy
volunteers. In patients, systolic BP was associated with TBW (P = 0.016), extracellular water
(ECW Lt; r = 0.99), ECW% (r = 0.78) and diastolic BP with TBW% (P = 0.003), dry weight (r =
0.76) ECW% (r = 0.95) and percent intracellular water (ICW%) (r = 0.79). Compared with controls,
ECW and ECW% was higher in patients, and the ICW% was less in patients. There was
significant difference in the actual weight of the patients and BIA-derived dry weight, although
patients were clinically not edematous. The study showed a significant increase in diastolic BP
with increase in dry weight. Significant difference in TBW was observed when the patients were
grouped on the basis of the antihypertensive medication a patient was taking (one antihypertensive
drug versus more than one antihypertensive drug). This study also showed an association
between hypertension and overhydration. BIA may be a useful tool for the clinical assessment of
overhydration in non-edematous patients.
Publisher
Saudi Center for Organ Transplantation,Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Wolters Kluwer Medknow Publications
Subject
/ Adult
/ Antihypertensive Agents - therapeutic use
/ Blood Pressure - drug effects
/ Diseases
/ Female
/ Humans
/ Hypertension - physiopathology
/ Kidney Transplantation - adverse effects
/ Kidneys
/ Male
/ Water-Electrolyte Imbalance - etiology
/ Water-Electrolyte Imbalance - metabolism
/ Water-Electrolyte Imbalance - physiopathology
/ ارتفاع ضغط الدم الوعائي الكلوي
/ الكلى
/ المرضى
