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Sugar Alcohols and Organic Acids Synthesis in Yarrowia lipolytica: Where Are We?
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Journal Article
Sugar Alcohols and Organic Acids Synthesis in Yarrowia lipolytica: Where Are We?
2020
Overview
Sugar alcohols and organic acids that derive from the metabolism of certain microorganisms have a panoply of applications in agro-food, chemical and pharmaceutical industries. The main challenge in their production is to reach a productivity threshold that allow the process to be profitable. This relies on the construction of efficient cell factories by metabolic engineering and on the development of low-cost production processes by using industrial wastes or cheap and widely available raw materials as feedstock. The non-conventional yeast Yarrowia lipolytica has emerged recently as a potential producer of such metabolites owing its low nutritive requirements, its ability to grow at high cell densities in a bioreactor and ease of genome edition. This review will focus on current knowledge on the synthesis of the most important sugar alcohols and organic acids in Y. lipolytica.
Publisher
MDPI AG,MDPI
Subject
