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Phosphorylation of H2A by Bub1 Prevents Chromosomal Instability Through Localizing Shugoshin

by Watanabe, Yoshinori , Yamagishi, Yuya , Honda, Takashi , Ishiguro, Kei-ichiro , Kawashima, Shigehiro A

in alanine / Animals / Antibodies / Biochemistry / Biological and medical sciences / carcinogenesis / Cell cycle, cell proliferation / Cell physiology / Cellular biology / Centromere - metabolism / Centromeres / Chromosomal Instability / Chromosomal Proteins, Non-Histone - genetics / Chromosomal Proteins, Non-Histone - metabolism / Chromosome Segregation / Chromosomes / Chromosomes, Fungal - metabolism / eukaryotic cells / Fundamental and applied biological sciences. Psychology / Germ cells / HeLa cells / histones / Histones - metabolism / Humans / Kinases / Kinetochores - metabolism / Meiosis / Metaphase / Mice / Mitosis / Molecular and cellular biology / mutants / Nucleosomes - metabolism / Phosphorylation / protein kinases / Protein-Serine-Threonine Kinases - genetics / Protein-Serine-Threonine Kinases - metabolism / Proteins / Recombinant Proteins - metabolism / Research Article / Saccharomyces cerevisiae - genetics / Saccharomyces cerevisiae - metabolism / Saccharomyces cerevisiae Proteins - genetics / Saccharomyces cerevisiae Proteins - metabolism / Schizosaccharomyces - cytology / Schizosaccharomyces - genetics / Schizosaccharomyces - metabolism / Schizosaccharomyces pombe / Schizosaccharomyces pombe Proteins - genetics / Schizosaccharomyces pombe Proteins - metabolism / serine / Serine - metabolism / Yeast / Yeasts

2010

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Phosphorylation of H2A by Bub1 Prevents Chromosomal Instability Through Localizing Shugoshin

by Watanabe, Yoshinori , Yamagishi, Yuya , Honda, Takashi , Ishiguro, Kei-ichiro , Kawashima, Shigehiro A

2010

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Phosphorylation of H2A by Bub1 Prevents Chromosomal Instability Through Localizing Shugoshin

by Watanabe, Yoshinori , Yamagishi, Yuya , Honda, Takashi , Ishiguro, Kei-ichiro , Kawashima, Shigehiro A

2010

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Journal Article

Phosphorylation of H2A by Bub1 Prevents Chromosomal Instability Through Localizing Shugoshin

Watanabe, Yoshinori,

Yamagishi, Yuya,

Honda, Takashi,

Ishiguro, Kei-ichiro,

Kawashima, Shigehiro A

2010

Overview

Bub1 is a multi-task protein kinase required for proper chromosome segregation in eukaryotes. Impairment of Bub1 in humans may lead to chromosomal instability (CIN) or tumorigenesis. Yet, the primary cellular substrate of Bub1 has remained elusive. Here, we show that Bub1 phosphorylates the conserved serine 121 of histone H2A in fission yeast Schizosaccharomyces pombe. The h2a-SA mutant, in which all cellular H2A-S121 is replaced by alanine, phenocopies the bub1 kinase-dead mutant (bub1-KD) in losing the centromeric localization of shugoshin proteins. Artificial tethering of shugoshin to centromeres largely restores the h2a-SA or bub1-KD-related CIN defects, a function that is evolutionally conserved. Thus, Bub1 kinase creates a mark for shugoshin localization and the correct partitioning of chromosomes.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

alanine

/ Animals

/ Antibodies

/ Biochemistry

/ Biological and medical sciences

/ carcinogenesis

/ Cell cycle, cell proliferation