Journal Article

Treatment Delays and In-Hospital Outcomes In Acute Myocardial Infarction During The Covid-19 Pandemic: A Nationwide Study

Erol, Mustafa Kemal

2020

Overview

Delayed admission of myocardial infarction (MI) patients is an important prognostic factor. In the present nationwide registry (TURKMI-2), we evaluated the treatment delays and outcomes of patients with acute MI during the Covid-19 pandemic and compaired with a recentpre-pandemic registry (TURKMI-1). The pandemic and pre-pandemic studies were conducted prospectively as 15-day snapshot registries in the same 48 centers. The inclusion criteria for both registries were aged ≥18 years and a final diagnosis of acute MI (AMI) with positive troponin levels. The only difference between the 2 registries was that the pre-pandemic (TURKMI-1) registry (n=1872) included only patients presenting within the first 48 hours after symptom-onset. TURKMI-2 enrolled all consecutive patients (n=1113) presenting with AMI during the pandemic period. A comparison of the patients with acute MI presenting within the 48-hour of symptom-onset in the pre-pandemic and pandemic registries revealed an overall 47.1% decrease in acute MI admissions during the pandemic. Median time from symptom-onset to hospital-arrival increased from 150 min to 185 min in patients with ST elevation MI (STEMI) and 295 min to 419 min in patients presenting with non-STEMI (NSTEMI) (p-values <0.001). Door-to-balloon time was similar in the two periods (37 vs. 40 min, p=0.448). In the pandemic period, percutaneous coronary intervention (PCI) decreased, especially in the NSTEMI group (60.3% vs. 47.4% in NSTEMI, p<0.001; 94.8% vs. 91.1% in STEMI, p=0.013) but the decrease was not significant in STEMI patients admitted within 12 hours of symptom-onset (94.9% vs. 92.1%; p=0.075). In-hospital major adverse cardiac events (MACE) were significantly increased during the pandemic period [4.8% vs. 8.9%; p<0.001; age- and sex-adjusted Odds ratio (95% CI) 1.96 (1.20-3.22) for NSTEMI, p=0.007; and 2.08 (1.38-3.13) for STEMI, p<0.001]. The present comparison of 2 nationwide registries showed a significant delay in treatment of patients presenting with acute MI during the COVID-19 pandemic. Although PCI was performed in a timely fashion, an increase in treatment delay might be responsible for the increased risk of MACE. Public education and establishing COVID-free hospitals are necessary to overcome patients' fear of using healthcare services and mitigate the potential complications of AMI during the pandemic. (Anatol J Cardiol 2020; 24: 334-42).

• Publisher: Kare Publishing,KARE Publishing
• Subject: acute myocardial infarction / Aged / Coronary Angiography - statistics & numerical data / Coronavirus Infections - epidemiology / COVID-19 / Emergency Medical Services - statistics & numerical data / Female / Heart Failure - mortality / Heart Failure - therapy / Humans / Male / Middle Aged / Myocardial Infarction - mortality / Myocardial Infarction - therapy / Original Investigation / pandemic / Pandemics - statistics & numerical data / Percutaneous Coronary Intervention - statistics & numerical data / Pneumonia, Viral - epidemiology / Prognosis / Registries / Regression Analysis / Shock, Cardiogenic - etiology / Shock, Cardiogenic - mortality / ST Elevation Myocardial Infarction - mortality / ST Elevation Myocardial Infarction - therapy / Time Factors / Time-to-Treatment - statistics & numerical data / total ischemic time / treatment delay / Treatment Outcome / Turkey - epidemiology