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Homodimeric Cross-Over Structure of the Human Granulocyte Colony-Stimulating Factor (GCSF) Receptor Signaling Complex
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Homodimeric Cross-Over Structure of the Human Granulocyte Colony-Stimulating Factor (GCSF) Receptor Signaling Complex
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Homodimeric Cross-Over Structure of the Human Granulocyte Colony-Stimulating Factor (GCSF) Receptor Signaling Complex
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Journal Article
Homodimeric Cross-Over Structure of the Human Granulocyte Colony-Stimulating Factor (GCSF) Receptor Signaling Complex
2006
Overview
A crystal structure of the signaling complex between human granulocyte colony-stimulating factor (GCSF) and a ligand binding region of GCSF receptor (GCSF-R), has been determined to 2.8 Å resolution. The GCSF:GCSF-R complex formed a 2:2 stoichiometry by means of a cross-over interaction between the Ig-like domains of GCSF-R and GCSF. The conformation of the complex is quite different from that between human GCSF and the cytokine receptor homologous domain of mouse GCSF-R, but similar to that of the IL-6/gp130 signaling complex. The Ig-like domain cross-over structure necessary for GCSF-R activation is consistent with previously reported thermodynamic and mutational analyses.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Atoms
/ Biology
/ Cells
/ Cytokine Receptor gp130 - chemistry
/ Cytokine Receptor gp130 - metabolism
/ Granulocyte Colony-Stimulating Factor - chemistry
/ Granulocyte Colony-Stimulating Factor - genetics
/ Granulocyte Colony-Stimulating Factor - metabolism
/ Humans
/ Ligands
/ Protein Structure, Quaternary
/ Proteins
/ Receptors, Granulocyte Colony-Stimulating Factor - chemistry
/ Receptors, Granulocyte Colony-Stimulating Factor - genetics
/ Receptors, Granulocyte Colony-Stimulating Factor - metabolism
