Asset Details
Do you wish to reserve the book?
Agrin and Perlecan Mediate Tumorigenic Processes in Oral Squamous Cell Carcinoma
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Agrin and Perlecan Mediate Tumorigenic Processes in Oral Squamous Cell Carcinoma
Do you wish to request the book?
Agrin and Perlecan Mediate Tumorigenic Processes in Oral Squamous Cell Carcinoma
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Agrin and Perlecan Mediate Tumorigenic Processes in Oral Squamous Cell Carcinoma
2014
Overview
Oral squamous cell carcinoma is the most common type of cancer in the oral cavity, representing more than 90% of all oral cancers. The characterization of altered molecules in oral cancer is essential to understand molecular mechanisms underlying tumor progression as well as to contribute to cancer biomarker and therapeutic target discovery. Proteoglycans are key molecular effectors of cell surface and pericellular microenvironments, performing multiple functions in cancer. Two of the major basement membrane proteoglycans, agrin and perlecan, were investigated in this study regarding their role in oral cancer. Using real time quantitative PCR (qRT-PCR), we showed that agrin and perlecan are highly expressed in oral squamous cell carcinoma. Interestingly, cell lines originated from distinct sites showed different expression of agrin and perlecan. Enzymatically targeting chondroitin sulfate modification by chondroitinase, oral squamous carcinoma cell line had a reduced ability to adhere to extracellular matrix proteins and increased sensibility to cisplatin. Additionally, knockdown of agrin and perlecan promoted a decrease on cell migration and adhesion, and on resistance of cells to cisplatin. Our study showed, for the first time, a negative regulation on oral cancer-associated events by either targeting chondroitin sulfate content or agrin and perlecan levels.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Antineoplastic Agents - pharmacology
/ Cancer
/ Carcinoma, Squamous Cell - genetics
/ Carcinoma, Squamous Cell - physiopathology
/ Drug Resistance, Neoplasm - genetics
/ Drug Resistance, Neoplasm - physiology
/ Heparan Sulfate Proteoglycans - genetics
/ Heparan Sulfate Proteoglycans - physiology
/ Humans
/ Medicine and Health Sciences
/ Mouth Neoplasms - physiopathology
/ Oral squamous cell carcinoma
/ Perlecan
/ Proteins
/ Sulfates
