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Fractional Flow Reserve–Guided PCI versus Medical Therapy in Stable Coronary Disease
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Journal Article
Fractional Flow Reserve–Guided PCI versus Medical Therapy in Stable Coronary Disease
2012
Overview
In this trial, fractional flow reserve was used to assess the functional significance of coronary stenoses in patients with clinically stable coronary artery disease. The clinical outcomes were better when this technique was used to direct the use of coronary stenting.
Percutaneous coronary intervention (PCI) improves the outcome in patients with acute coronary syndromes.
1
In contrast, for the treatment of patients with stable coronary artery disease, controversy persists regarding the extent of the benefit from PCI, as compared with the best available medical therapy, as an initial management strategy.
2
–
5
The potential benefit of revascularization depends on the presence and extent of myocardial ischemia.
6
–
8
Performing PCI on nonischemic stenoses is not beneficial
9
and is probably harmful.
10
Thus, careful selection of ischemia-inducing stenoses is essential for deriving the greatest benefit from revascularization in patients with stable coronary artery disease.
Fractional flow . . .
Publisher
Massachusetts Medical Society
Subject
/ Adrenergic beta-1 Receptor Antagonists
/ Aged
/ Angioplasty, Balloon, Coronary - methods
/ Angiotensin-Converting Enzyme Inhibitors - therapeutic use
/ Biological and medical sciences
/ Coronary Disease - drug therapy
/ Coronary Disease - mortality
/ EKG
/ Female
/ Fractional Flow Reserve, Myocardial
/ Heart
/ Humans
/ Ischemia
/ Male
/ Myocardial Infarction - epidemiology
/ Myocardial Infarction - prevention & control
/ Patients
/ Platelet Aggregation Inhibitors - therapeutic use
/ Stenosis
