Journal Article

Comparing survival outcomes of anti-fibrotic therapy for idiopathic pulmonary fibrosis with and without emphysema: a multi-center real-world study from Taiwan

Lin, Yu-Ching, Fang, Yu-Hung, Wei, Yu-Feng, Hsieh, Yi-An, Chiu, Yu-Chi, Huang, Chien-Wen, Chen, Yen-Fu, Fu, Pin-Kuei, Huang, Yung-Chia, Huang, Kuo-Tung

2025

Overview

Background Whether the long-term survival of patients with idiopathic pulmonary fibrosis (IPF) is worse than that of patients with IPF combined with emphysema after anti-fibrotic therapy is unclear. This study aimed to compare treatment outcomes between the two groups and identify potential predictors of mortality. Methods This retrospective cohort study was conducted in seven hospitals across Taiwan between August 2015 and August 2022 and included patients with IPF who received anti-fibrotic agents covered by national insurance. Based on the extent of emphysema observed on high-resolution chest tomography, patients with IPF were categorized into two groups: IPF only; and IPF with emphysema. Baseline characteristics and survival outcomes were compared between the groups. Cox proportional hazards models were used for multivariable analysis to identify factors associated with overall mortality during the follow-up period. Results Of the 275 patients included, 126 (45.8%) had IPF with emphysema and 149 (54.2%) had IPF only. The emphysema group had a higher proportion of males and patients with a smoking history, finger clubbing, comorbidities, or a definite usual interstitial pneumonia (UIP) pattern compared to the IPF-only group. Additionally, this group had a higher forced vital capacity (FVC, %) and forced expiratory volume in 1 s (FEV₁, L), while FEV₁ (%) was similar and FEV₁/FVC (%) was lower. During a median follow-up of 3.7 years, the overall survival rates were comparable (IPF only: 45.6%; IPF with emphysema: 48.4%). The overall survival of patients with probable UIP was significantly better than that of patients with definite UIP (53.5% vs. 34.6%). Likewise, the survival rate of the group with a diffusing capacity of the lung for carbon monoxide (DLCO) > 49% was higher than that of the group with DLCO ≤ 49% (53.9% vs. 31.4%). After adjusting for confounders, lower body mass index (BMI) (adjusted hazard ratio [aHR] = 0.95) and comorbid pulmonary hypertension (aHR = 2.27) were independently associated with increased overall mortality. Neither the presence of emphysema nor the type of anti-fibrotic agent was associated with mortality. Conclusions The survival outcomes of patients with IPF and emphysema and those of patients with IPF only are comparable after treatment with anti-fibrotic agents. Lower BMI and comorbid pulmonary hypertension are significant predictors of increased mortality.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Aged / Analysis / Anti-fibrotic Therapy / Antifibrotic Agents - therapeutic use / Body mass index / Carbon monoxide / Care and treatment / Chronic obstructive pulmonary disease / Clinical outcomes / Cohort analysis / Comorbidity / Complications and side effects / Critical Care Medicine / Diagnosis / Dosage and administration / Emphysema / Emphysema, Pulmonary / Enrollments / Female / Fibrosis / Forced Expiratory Volume / Humans / Hypertension / Idiopathic Pulmonary Fibrosis (IPF) / Idiopathic Pulmonary Fibrosis - complications / Idiopathic Pulmonary Fibrosis - drug therapy / Idiopathic Pulmonary Fibrosis - mortality / Idiopathic Pulmonary Fibrosis - physiopathology / Intensive / Internal Medicine / Lung diseases / Male / Medicine / Medicine & Public Health / Middle Aged / Mortality / Patient outcomes / Patients / Phosphotransferases / Pneumology/Respiratory System / Proportional Hazards Models / Pulmonary Emphysema - complications / Pulmonary Emphysema - drug therapy / Pulmonary Emphysema - mortality / Pulmonary Emphysema - physiopathology / Pulmonary fibrosis / Pulmonary function tests / Pulmonary Hypertension / Reimbursement / Retrospective Studies / Statistical analysis / Survival / Survival analysis / Survival Outcomes / Taiwan - epidemiology / Tomography, X-Ray Computed / Treatment Outcome / Vital Capacity