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Single cell transcriptomics of the cerebral cortex of mice lacking the PRC2 gene eed
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Journal Article
Single cell transcriptomics of the cerebral cortex of mice lacking the PRC2 gene eed
2024
Overview
Objective
The Polycomb Repressive Complex 2 (PRC2) regulates neural stem cell behaviour during development of the cerebral cortex, yet how the loss of PRC2 developmentally influences cell identity in the mature brain is poorly defined. Using a mouse model in which the PRC2 gene
Embryonic ectoderm development
(
Eed)
was conditionally deleted from the developing mouse dorsal telencephalon, we performed single nuclei RNA sequencing (snRNA-seq) on the cortical plate of an adult heterozygote
Eed
knockout mouse and an adult homozygote
Eed
knockout mouse compared to a littermate control. This work was part of a larger effort to understand consequences of mutations to PRC2 within the mature brain.
Results
Here we provide snRNA-seq data from the cortical plate of an adult heterozygous conditional
Eed
knockout, an adult homozygous conditional
Eed
knockout and an adult control mouse. This data provides insight on how loss of PRC2 function during development affects cell identity in the mature cortex.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Biomedical and Life Sciences
/ Cells
/ Cerebral Cortex - embryology
/ Cerebral Cortex - metabolism
/ Datasets
/ Ectoderm
/ Eed
/ Genomes
/ Genomics
/ Methods
/ Mice
/ Polycomb repressive complex 2 (PRC2)
/ Polycomb Repressive Complex 2 - deficiency
/ Polycomb Repressive Complex 2 - genetics
/ Polycomb Repressive Complex 2 - metabolism
/ Single nuclei RNA-sequencing (snRNA-seq)
/ Single-Cell Analysis - methods
/ snRNA
/ Zygosity
