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The elevated levels of soluble growth stimulation expressed gene 2 are associated with coronary atherosclerotic plaque destabilization in unstable angina patients: a case control study
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The elevated levels of soluble growth stimulation expressed gene 2 are associated with coronary atherosclerotic plaque destabilization in unstable angina patients: a case control study
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The elevated levels of soluble growth stimulation expressed gene 2 are associated with coronary atherosclerotic plaque destabilization in unstable angina patients: a case control study
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Journal Article
The elevated levels of soluble growth stimulation expressed gene 2 are associated with coronary atherosclerotic plaque destabilization in unstable angina patients: a case control study
2025
Overview
Background
Plaque destabilization and rupture are the primary triggers of acute coronary syndrome (ACS). Soluble growth stimulation expressed gene 2 (sST2) has been implicated in cardiovascular disease. We aimed to investigate the association between circulating sST2 levels and features of coronary plaque destabilization assessed by optical coherence tomography (OCT) in patients with unstable angina (UA).
Methods
This study enrolled 122 patients admitted with UA and 107 age- and sex-matched healthy controls. All UA patients underwent standard coronary angiography and OCT imaging to identify features indicative of plaque destabilization. Plasma sST2 levels were measured in all participants using an immunofluorescence assay. Associations between sST2 levels, clinical characteristics, and factors predicting OCT-defined plaque destabilization were analyzed.
Results
sST2 levels were significantly higher in UA patients compared to healthy controls (
p
< 0.001). Among UA patients, sST2 levels were significantly elevated in those with OCT-defined plaque destabilization features compared to those without (
p
< 0.001). In multivariable logistic regression analysis, elevated sST2 levels emerged as an independent factor associated with the presence of OCT-defined plaque destabilization (
p
= 0.013).
Conclusions
Circulating sST2 levels are elevated in UA patients and independently associated with features of coronary plaque destabilization identified by OCT. These findings suggest sST2 may be a novel biomarker reflecting plaque destabilization in patients with UA, potentially aiding in risk stratification.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Aged
/ Analysis
/ Angina
/ Angina, Unstable - diagnostic imaging
/ Atherosclerotic coronary plaque
/ Complications and side effects
/ Coronary Artery Disease - blood
/ Coronary Artery Disease - diagnostic imaging
/ Coronary Vessels - diagnostic imaging
/ Diabetes
/ Female
/ Growth stimulation expressed gene 2
/ Humans
/ Interleukin-1 Receptor-Like 1 Protein - blood
/ Male
/ Medicine
/ Optical coherence tomography
/ Patients
