Asset Details
Do you wish to reserve the book?
Sleep disturbances, shift work, and epigenetic ageing in working-age adults: findings from the Young Finns study
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Sleep disturbances, shift work, and epigenetic ageing in working-age adults: findings from the Young Finns study
Do you wish to request the book?
Sleep disturbances, shift work, and epigenetic ageing in working-age adults: findings from the Young Finns study
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Sleep disturbances, shift work, and epigenetic ageing in working-age adults: findings from the Young Finns study
2025
Overview
Background
Sleep disturbances are known to have adverse effects on health, but knowledge on the effect of sleep disturbances on epigenetic ageing is limited. We investigated (1) whether symptoms of insomnia, obstructive sleep apnoea, sleep deprivation, and circadian rhythm lateness are associated with epigenetic ageing, and (2) whether years spent in shift work moderates these associations.
Methods
We used the population-based Young Finns data (
n
= 1618). Epigenetic clocks such as AgeDev
Hannum
, AgeDev
Horvath
, AgeDev
Pheno
, AgeDev
Grim
, and DunedinPACE were utilized to measure epigenetic ageing. Sleep was evaluated using various validated self-report questionnaires. Covariates included sex, array type, smoking status, health behaviours, socioeconomic factors, and cardiovascular health factors.
Results
Among the various sleep measures, obstructive sleep apnoea symptoms were most consistently linked to accelerated epigenetic ageing, as measured by AgeDev
Grim
and DunedinPACE. Insomnia, sleep deprivation, and years spent in shift work were not associated with epigenetic ageing after adjusting for health-related or socioeconomic covariates. Additionally, we found interactions between years spent in shift work and sleep disturbances when accounting for epigenetic ageing. Among those with little to no history of shift work, both insomnia and sleep deprivation were associated with more accelerated epigenetic ageing in AgeDev
Grim
when compared to long-term shift workers. However, the pace of epigenetic ageing (measured with DunedinPACE) appears to be higher in those with both sleep deprivation and longer history of shift work.
Conclusions
Among various sleep measures, symptoms of obstructive sleep apnoea appear to be most consistently associated with accelerated epigenetic ageing even after adjusting for various health-related and socioeconomic factors. Shift work seems to have a crucial role in the relationship between sleep disturbances and epigenetic ageing in working-age adults.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Adults
/ Age
/ Aging
/ Apnea
/ Biomedical and Life Sciences
/ Diabetes
/ Epigenetics of Sleep Disorders
/ Female
/ Genomes
/ Humans
/ Insomnia
/ Male
/ Shift Work Schedule - adverse effects
/ Sleep Apnea, Obstructive - genetics
/ Sleep Initiation and Maintenance Disorders - genetics
/ Sleep Wake Disorders - genetics
/ Surveys
/ Validity
