Asset Details
Do you wish to reserve the book?
“Pour some sugar on me”—Environmental Candida albicans isolates and the evolution of increased pathogenicity and antifungal resistance through sugar adaptation
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
“Pour some sugar on me”—Environmental Candida albicans isolates and the evolution of increased pathogenicity and antifungal resistance through sugar adaptation
Do you wish to request the book?
“Pour some sugar on me”—Environmental Candida albicans isolates and the evolution of increased pathogenicity and antifungal resistance through sugar adaptation
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
“Pour some sugar on me”—Environmental Candida albicans isolates and the evolution of increased pathogenicity and antifungal resistance through sugar adaptation
2025
Overview
Candida albicans is an opportunistic fungal pathogen that colonizes mucosal surfaces of most humans. Only in rare cases, C. albicans isolates are found in the environment. This study investigated whether environmental isolates differ in their virulence potential from clinical strains and how adaptation to a human diet influences key virulence attributes. We examined three C. albicans isolates from oak trees in the United Kingdom, and observed that one exhibited high host cell damage, increased hypha formation, invasion capacity, and candidalysin production, along with an intrinsic resistance to amphotericin B. The other two showed lower virulence which was still similar to most tested clinical isolates. All oak tree isolates showed an increased resistance to fluconazole. To mimic the more recent evolution of C. albicans to a sugar-rich diet, we evolved a low-damaging isolate in sugar-rich medium, which unexpectedly enhanced its metabolic flexibility, epithelial damage potential, and antifungal resistances, including a new resistance to amphotericin B. These findings suggest that C. albicans isolates can develop high virulence potential and antifungal resistance in the environment, and that adaptation of C. albicans to sugar-rich diets, as in westernized countries, can affect fungal pathogenicity and drug resistance.
Publisher
Public Library of Science,PLOS,Public Library of Science (PLoS)
Subject
/ Amphotericin B - pharmacology
/ Analysis
/ Antifungal Agents - pharmacology
/ Candida albicans - drug effects
/ Candida albicans - isolation & purification
/ Candida albicans - pathogenicity
/ Drug resistance in microorganisms
/ Humans
/ Medicine and Health Sciences
