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Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria
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Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria
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Journal Article
Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria
2006
Overview
Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Bacteria
/ Biological and medical sciences
/ Cells
/ Enzymes
/ Fundamental and applied biological sciences. Psychology
/ Genetics of the immune response
/ GTP-Binding Proteins - genetics
/ GTP-Binding Proteins - physiology
/ Humans
/ Interferon-gamma - immunology
/ Mice
/ Microtubule-Associated Proteins - metabolism
/ Mycobacterium bovis - immunology
/ Mycobacterium bovis - physiology
/ Proteins
/ Vacuoles
