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The P2X7 Receptor is a Master Regulator of Microparticle and Mitochondria Exchange in Mouse Microglia

by Morciano, Giampaolo , Tarantini, Mario , Tang, Yong , Di Virgilio, Francesco , Chiozzi, Paola , Giuliani, Anna Lisa , Vultaggio-Poma, Valentina , Adinolfi, Elena , Falzoni, Simonetta , Boldrini, Paola , Gorecki, Dariusz C

in Adenosine Triphosphate - metabolism / Animals / Cell differentiation / Cell interactions / Cell Line / Cell lines / Cell-Derived Microparticles - metabolism / inflammation / Mice / Mice, Knockout / Microglia / Microglia - metabolism / Microparticles / Mitochondria / Mitochondria - metabolism / NLR Family, Pyrin Domain-Containing 3 Protein - genetics / NLR Family, Pyrin Domain-Containing 3 Protein - metabolism / Original Research / P2X7 receptor / Phenotypes / Receptors, Purinergic P2X7 - genetics / Receptors, Purinergic P2X7 - metabolism

2024

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The P2X7 Receptor is a Master Regulator of Microparticle and Mitochondria Exchange in Mouse Microglia

2024

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The P2X7 Receptor is a Master Regulator of Microparticle and Mitochondria Exchange in Mouse Microglia

2024

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Journal Article

The P2X7 Receptor is a Master Regulator of Microparticle and Mitochondria Exchange in Mouse Microglia

Morciano, Giampaolo,

Tarantini, Mario,

Tang, Yong,

Di Virgilio, Francesco,

Chiozzi, Paola,

Giuliani, Anna Lisa,

Vultaggio-Poma, Valentina,

Adinolfi, Elena,

Falzoni, Simonetta,

Boldrini, Paola,

Gorecki, Dariusz C

2024

Overview

Microparticles (MPs) are secreted by all cells, where they play a key role in intercellular communication, differentiation, inflammation, and cell energy transfer. P2X7 receptor (P2X7R) activation by extracellular ATP (eATP) causes a large MP release and affects their contents in a cell-specific fashion. We investigated MP release and functional impact in microglial cells from P2X7R-WT or P2X7R-KO mice, as well as mouse microglial cell lines characterized for high (N13-P2X7RHigh) or low (N13-P2X7RLow) P2X7R expression. P2X7R stimulation promoted release of a mixed MP population enriched with naked mitochondria. Released mitochondria were taken up and incorporated into the mitochondrial network of the recipient cells in a P2X7R-dependent fashion. NLRP3 and the P2X7R itself were also delivered to the recipient cells. Microparticle transfer increased the energy level of the recipient cells and conferred a pro-inflammatory phenotype. These data show that the P2X7R is a master regulator of intercellular organelle and MP trafficking in immune cells. Graphical Abstract Graphical Abstract

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Publisher

Oxford University Press,American Physiological Society

Subject

Adenosine Triphosphate - metabolism

/ Animals

/ Cell differentiation

/ Cell interactions

/ Cell Line

/ Cell lines

/ Cell-Derived Microparticles - metabolism