Journal Article

The effect of anti-TNF treatment on the immunogenicity and safety of the 7-valent conjugate pneumococcal vaccine in children with juvenile idiopathic arthritis

Theodoridou, Maria, Kanakoudi-Tsakalidou, Florentia, Pratsidou-Gertsi, Polyxeni, Spoulou, Vana, Farmaki, Evangelia, Tritsoni, Maria, Trachana, Maria

2010

Overview

Our aim was to study the effect of anti-TNF treatment on immunogenicity and safety of the 7-valent conjugate pneumococcal vaccine in children with juvenile idiopathic arthritis. Thirty-one children (mean age:12.9 ± 4.6 years) treated with anti-TNFs plus Disease Modifying Anti-Rheumatic Drugs (DMARDs) and 32 age-matched children treated only with DMARDs were vaccinated with two doses of PCV7. After the first vaccine dose geometric mean titers (GMTs) were significantly increased for all vaccine serotypes ( p < 0.0001) in both groups and were found to be protective (>0.35 μg/ml) in 87–100% of all children, depending on the serotype. Children receiving anti-TNFs achieved a significantly lower GMTs against serotypes 4, 14 and 23F ( p < 0.05). A ≥4-fold increase of the baseline titers to ≥5 vaccine serotypes was observed in 50% and 75% of the anti-TNF and control patients, respectively ( p = 0.0697). No patient developed vaccine-associated serious adverse events or disease flares.

• Publisher: Elsevier Ltd,Elsevier,Elsevier Limited
• Subject: 7-Valent conjugate pneumococcal vaccine / Adolescent / Allergy and Immunology / Anti-TNF agents / Antibodies, Bacterial - blood / Antirheumatic Agents - therapeutic use / Applied microbiology / Arthritis / Arthritis, Juvenile - drug therapy / Arthritis, Juvenile - immunology / Bacteriology / Biological and medical sciences / Child / Child, Preschool / Cyclosporine - therapeutic use / Female / Fundamental and applied biological sciences. Psychology / Heptavalent Pneumococcal Conjugate Vaccine / Humans / Immunization / Immunogenicity / Juvenile idiopathic arthritis / Male / Methotrexate - therapeutic use / Microbiology / Miscellaneous / Mortality / Pneumococcal Vaccines - adverse effects / Pneumococcal Vaccines - immunology / Prednisone - therapeutic use / Streptococcus pneumoniae / Studies / Tumor Necrosis Factor-alpha - antagonists & inhibitors / Vaccines / Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) / Vaccines, Conjugate - adverse effects / Vaccines, Conjugate - immunology