Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Degradative transport of cationic amphiphilic drugs across phospholipid bilayers

by Ces, Oscar , Mulet, Xavier , Parker, Christine A , Clarke, James A , Sebai, Sarra C , Shearman, Gemma C , Plisson, Christophe , Law, Robert V , Baciu, Magdalena , Templer, Richard H , Gee, Antony

in Biological Transport, Active / Cations / Cell membranes / Computer aided design / Diffusion / Drug Delivery / Drug Delivery Systems / Esters / Fluorescence / Hydrolysis / In Vitro Techniques / Lipid Bilayers - chemistry / Lipid Bilayers - metabolism / Lipids / Liquid Crystals / Magnetic Resonance Spectroscopy / Membrane / Micelles / Microscopy, Fluorescence / Models, Biological / Molecules / Nuclear magnetic resonance / Passive Diffusion / Phospholipid Degradation / Phospholipids / Phospholipids - chemistry / Phospholipids - metabolism / Scattering, Radiation / Surface-Active Agents - chemistry / Surface-Active Agents - pharmacokinetics / Translocation / X-Rays

2006

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Degradative transport of cationic amphiphilic drugs across phospholipid bilayers

by Ces, Oscar , Mulet, Xavier , Parker, Christine A , Clarke, James A , Sebai, Sarra C , Shearman, Gemma C , Plisson, Christophe , Law, Robert V , Baciu, Magdalena , Templer, Richard H , Gee, Antony

2006

Confirm

Do you wish to request the book?

Degradative transport of cationic amphiphilic drugs across phospholipid bilayers

by Ces, Oscar , Mulet, Xavier , Parker, Christine A , Clarke, James A , Sebai, Sarra C , Shearman, Gemma C , Plisson, Christophe , Law, Robert V , Baciu, Magdalena , Templer, Richard H , Gee, Antony

2006

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Degradative transport of cationic amphiphilic drugs across phospholipid bilayers

Ces, Oscar,

Mulet, Xavier,

Parker, Christine A,

Clarke, James A,

Sebai, Sarra C,

Shearman, Gemma C,

Plisson, Christophe,

Law, Robert V,

Baciu, Magdalena,

Templer, Richard H,

Gee, Antony

2006

Overview

Drug molecules must cross multiple cell membrane barriers to reach their site of action. We present evidence that one of the largest classes of pharmaceutical drug molecules, the cationic amphiphilic drugs (CADs), does so via a catalytic reaction that degrades the phospholipid fabric of the membrane. We find that CADs partition rapidly to the polar-apolar region of the membrane. At physiological pH, the protonated groups on the CAD catalyse the acid hydrolysis of the ester linkage present in the phospholipid chains, producing a fatty acid and a single-chain lipid. The single-chain lipids rapidly destabilize the membrane, causing membranous fragments to separate and diffuse away from the host. These membrane fragments carry the drug molecules with them. The entire process, from drug adsorption to drug release within micelles, occurs on a time-scale of seconds, compatible with in vivo drug diffusion rates. Given the rate at which the reaction occurs, it is probable that this process is a significant mechanism for drug transport.

Share this book

Add to My Shelf

Publisher

The Royal Society

Subject

Biological Transport, Active

/ Cations

/ Cell membranes

/ Computer aided design

/ Diffusion

/ Drug Delivery

/ Drug Delivery Systems