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24 h severe fluid restriction increases a biomarker of renal injury in healthy males
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24 h severe fluid restriction increases a biomarker of renal injury in healthy males
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Journal Article
24 h severe fluid restriction increases a biomarker of renal injury in healthy males
2025
Overview
Purpose
Exercise-induced hypohydration exacerbates biomarkers of renal injury, but studies isolating the effects of hypohydration without exercise have produced mixed findings. This study investigated the effects of 24-h severe fluid restriction on biomarkers of renal injury and glucose tolerance.
Methods
Fifteen males (age: 27 ± 5 y; BMI: 24.1 ± 3.8 kg/m
2
) completed two randomised trials, involving consuming either 40 mL/kg body mass water to maintain euhydration (EU) or severe fluid restriction via limiting water consumption to 100 mL (HYP). A standardised dry food diet was consumed in both trials (~ 300 g water). At baseline and 24 h post-baseline, nude body mass, and blood and urine samples (additional urine sample at 12 h) were collected. An oral glucose tolerance test was conducted after 24-h post-baseline measurements (
n
= 12).
Results
At 24 h, body mass loss (HYP: − 1.52 ± 0.34%, EU: − 0.24 ± 0.40%), plasma volume loss, serum, and urine osmolality were greater in HYP than EU (
P
≤ 0.004). Osmolality-corrected urinary kidney injury molecule-1 (uKIM-1) concentrations were greater in HYP at 12 (HYP: 1.097 ± 0.587 ng/mOsm, EU: 0.570 ± 0.408 ng/mOsm;
P
< 0.001) and 24-h (HYP: 1.932 ± 1.173 ng/mOsm, EU: 1.599 ± 1.012 ng/mOsm;
P
= 0.01). There was no trial-by-time interactions for osmolality-corrected urinary neutrophil gelatinase-associated lipocalin concentrations (
P
= 0.781) or plasma glucose (
P
= 0.550) and insulin (
P
= 0.193) concentrations.
Conclusion
Hypohydration produced by 24-h fluid restriction increased proximal tubular injury but did not affect glucose tolerance.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
