Asset Details
Do you wish to reserve the book?
Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice
Do you wish to request the book?
Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice
2012
Overview
Purpose
Curcumin has shown a variety of biological activity for various human diseases including cancer in preclinical setting. Its poor oral bioavailability poses significant pharmacological barriers to its clinical application. Here, we established a practical nano-emulsion curcumin (NEC) containing up to 20% curcumin (w/w) and conducted the pharmacokinetics of curcuminoids and curcumin metabolites in mice.
Methods
This high loading NEC was formulated based on the high solubility of curcumin in polyethylene glycols (PEGs) and the synergistic enhancement of curcumin absorption by PEGs and Cremophor EL. The pharmacokinetics of curcuminoids and curcumin metabolites was characterized in mice using a LC–MS/MS method, and the pharmacokinetic parameters were determined using WinNonlin computer software.
Results
A tenfold increase in the
AUC
0→24h
and more than 40-fold increase in the
C
max
in mice were observed after an oral dose of NEC compared with suspension curcumin in 1% methylcellulose. The plasma pharmacokinetics of its two natural congeners, demethoxycurcumin and bisdemethoxycurcumin, and three metabolites, tetrahydrocurcumin (THC), curcumin-
O
-glucuronide, and curcumin-
O
-sulfate, was characterized for the first time in mice after an oral dose of NEC.
Conclusion
This oral absorption enhanced NEC may provide a practical formulation to conduct the correlative study of the PK of curcuminoids and their pharmacodynamics, e.g., hypomethylation activity in vivo.
Publisher
Springer-Verlag,Springer,Springer Nature B.V
