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Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep

by Nolan, Michael A. , Wang, Karen , Weng, Feng-Ju , Zachs, Daniel P. , Gelwan, Noah A. , Goldblum, Rebecca R. , Ramos, Daniel M. , Kenny, Jonathan D. , Van Dort, Christa J. , Brown, Emery N. , Wilson, Matthew A. , Zheng, Shu , Lin, Yingxi

in Animals / Bacterial Proteins - genetics / Bacterial Proteins - metabolism / Biological Sciences / brain stem / Channelrhodopsins / Choline O-Acetyltransferase - genetics / Cholinergic Neurons - cytology / Cholinergic Neurons - physiology / Eye movements / eyes / Fiber Optic Technology / Luminescent Proteins - genetics / Luminescent Proteins - metabolism / Male / Mice / Mice, Transgenic / Neurons / Optogenetics / Promoter Regions, Genetic / Recombinant Fusion Proteins - genetics / Recombinant Fusion Proteins - metabolism / Sleep / Sleep, REM - genetics / Sleep, REM - physiology / Tegmentum Mesencephali - anatomy & histology / Tegmentum Mesencephali - physiology / Wakefulness - genetics / Wakefulness - physiology

2015

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Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep

2015

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Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep

2015

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Journal Article

Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep

Nolan, Michael A.,

Wang, Karen,

Weng, Feng-Ju,

Zachs, Daniel P.,

Gelwan, Noah A.,

Goldblum, Rebecca R.,

Ramos, Daniel M.,

Kenny, Jonathan D.,

Van Dort, Christa J.,

Brown, Emery N.,

Wilson, Matthew A.,

Zheng, Shu,

Lin, Yingxi

2015

Overview

Rapid eye movement (REM) sleep is an important component of the natural sleep/wake cycle, yet the mechanisms that regulate REM sleep remain incompletely understood. Cholinergic neurons in the mesopontine tegmentum have been implicated in REM sleep regulation, but lesions of this area have had varying effects on REM sleep. Therefore, this study aimed to clarify the role of cholinergic neurons in the pedunculopontine tegmentum (PPT) and laterodorsal tegmentum (LDT) in REM sleep generation. Selective optogenetic activation of cholinergic neurons in the PPT or LDT during non-REM (NREM) sleep increased the number of REM sleep episodes and did not change REM sleep episode duration. Activation of cholinergic neurons in the PPT or LDT during NREM sleep was sufficient to induce REM sleep.

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Publisher

National Academy of Sciences,National Acad Sciences

Subject

Animals

/ Bacterial Proteins - genetics

/ Bacterial Proteins - metabolism

/ Biological Sciences

/ brain stem

/ Channelrhodopsins

/ Choline O-Acetyltransferase - genetics