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Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
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Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
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Journal Article
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009
Overview
Lysine acetylation is a reversible posttranslational modification of proteins and plays a key role in regulating gene expression. Technological limitations have so far prevented a global analysis of lysine acetylation's cellular roles. We used high-resolution mass spectrometry to identify 3600 lysine acetylation sites on 1750 proteins and quantified acetylation changes in response to the deacetylase inhibitors suberoylanilide hydroxamic acid and MS-275. Lysine acetylation preferentially targets large macromolecular complexes involved in diverse cellular processes, such as chromatin remodeling, cell cycle, splicing, nuclear transport, and actin nucleation. Acetylation impaired phosphorylation-dependent interactions of 14-3-3 and regulated the yeast cyclin-dependent kinase Cdc28. Our data demonstrate that the regulatory scope of lysine acetylation is broad and comparable with that of other major posttranslational modifications.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ actin
/ Biological and medical sciences
/ Cell cycle, cell proliferation
/ Cell Physiological Phenomena
/ Enzyme Inhibitors - pharmacology
/ Fundamental and applied biological sciences. Psychology
/ Histone Deacetylase Inhibitors
/ Histone Deacetylases - metabolism
/ Histones
/ Humans
/ Hydroxamic Acids - pharmacology
/ lysine
/ Metabolic Networks and Pathways
/ Molecular and cellular biology
/ Multiprotein Complexes - chemistry
/ Multiprotein Complexes - metabolism
/ post-translational modification
/ Protein Processing, Post-Translational
/ Proteins
/ Saccharomyces cerevisiae - metabolism
/ Saccharomyces cerevisiae Proteins - metabolism
/ Transcription. Transcription factor. Splicing. Rna processing
/ Yeasts
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