Asset Details
Do you wish to reserve the book?
The role of survival motor neuron protein (SMN) in protein homeostasis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The role of survival motor neuron protein (SMN) in protein homeostasis
Do you wish to request the book?
The role of survival motor neuron protein (SMN) in protein homeostasis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The role of survival motor neuron protein (SMN) in protein homeostasis
2018
Overview
Ever since loss of survival motor neuron (SMN) protein was identified as the direct cause of the childhood inherited neurodegenerative disorder spinal muscular atrophy, significant efforts have been made to reveal the molecular functions of this ubiquitously expressed protein. Resulting research demonstrated that SMN plays important roles in multiple fundamental cellular homeostatic pathways, including a well-characterised role in the assembly of the spliceosome and biogenesis of ribonucleoproteins. More recent studies have shown that SMN is also involved in other housekeeping processes, including mRNA trafficking and local translation, cytoskeletal dynamics, endocytosis and autophagy. Moreover, SMN has been shown to influence mitochondria and bioenergetic pathways as well as regulate function of the ubiquitin–proteasome system. In this review, we summarise these diverse functions of SMN, confirming its key role in maintenance of the homeostatic environment of the cell.
Publisher
Springer International Publishing,Springer Nature B.V
Subject
/ Atrophy
/ Biomedical and Life Sciences
/ Children
/ Humans
/ mRNA
/ Muscular Atrophy, Spinal - genetics
/ Muscular Atrophy, Spinal - metabolism
/ Muscular Atrophy, Spinal - pathology
/ Mutation
/ Neurons
/ Proteins
/ Review
/ Ribonucleoproteins - genetics
/ Ribonucleoproteins - metabolism
/ SMN Complex Proteins - genetics
/ SMN Complex Proteins - metabolism
/ Survival
