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Diagnostic value of plasma and bronchoalveolar lavage samples in acute lung allograft rejection: differential cytology

by Schuurmans, Macé M. , Murer, Christian , Huber, Lars C. , Benden, Christian , Speck, Nicole E.

in Acute Disease / Algorithms / Allografts / Alveoli / Animals / Biomarkers - blood / Biopsy / Bronchoalveolar Lavage Fluid - chemistry / Bronchoalveolar Lavage Fluid - cytology / Bronchoscopy / Bronchus / Care and treatment / Cells / Cellular biology / Cytology / Diagnosis / Graft rejection / Graft Rejection - blood / Graft Rejection - diagnosis / Graft Rejection - metabolism / Graft Rejection - pathology / Humans / Infections / Lavage / Leukocytes - metabolism / Lung - metabolism / Lung - pathology / Lung diseases / Lung Transplantation - adverse effects / Lung transplants / Lungs / Lymphocytes / Macrophages - metabolism / Medical prognosis / Medicine / Medicine & Public Health / Neutrophils / Plasma / Pneumology/Respiratory System / Predictive Value of Tests / Prognosis / Rejection / Review / Transplantation

2016

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Diagnostic value of plasma and bronchoalveolar lavage samples in acute lung allograft rejection: differential cytology

by Schuurmans, Macé M. , Murer, Christian , Huber, Lars C. , Benden, Christian , Speck, Nicole E.

2016

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Diagnostic value of plasma and bronchoalveolar lavage samples in acute lung allograft rejection: differential cytology

by Schuurmans, Macé M. , Murer, Christian , Huber, Lars C. , Benden, Christian , Speck, Nicole E.

2016

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Journal Article

Diagnostic value of plasma and bronchoalveolar lavage samples in acute lung allograft rejection: differential cytology

Schuurmans, Macé M.,

Murer, Christian,

Huber, Lars C.,

Benden, Christian,

Speck, Nicole E.

2016

Overview

Diagnosis of acute lung allograft rejection is currently based on transbronchial lung biopsies. Additional methods to detect acute allograft dysfunction derived from plasma and bronchoalveolar lavage samples might facilitate diagnosis and ultimately improve allograft survival. This review article gives an overview of the cell profiles of bronchoalveolar lavage and plasma samples during acute lung allograft rejection. The value of these cells and changes within the pattern of differential cytology to support the diagnosis of acute lung allograft rejection is discussed. Current findings on the topic are highlighted and trends for future research are identified.

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Publisher

BioMed Central,BioMed Central Ltd,Nature Publishing Group

Subject

Acute Disease

/ Algorithms

/ Allografts

/ Alveoli

/ Animals

/ Biomarkers - blood

/ Biopsy