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Analysis of Bottlenecks in Experimental Models of Infection
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Analysis of Bottlenecks in Experimental Models of Infection
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Journal Article
Analysis of Bottlenecks in Experimental Models of Infection
2015
Overview
[...]genome-wide transposon insertion studies can be confounded by the existence of tight bottlenecks, which can limit the complexity of libraries that can effectively be analyzed. [...]when stochastic loss of transposon mutants due to bottlenecks overshadows the effects of fitness defects, many false positive classifications result [32]. [...]random differences may severely impact the accuracy and reliability of transmission chains constructed based on the genetic similarity between pathogen populations in different hosts [33]. [...]it is critical for high-throughput studies to account for bottleneck effects.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
