Asset Details
Do you wish to reserve the book?
Intracranial aneurysms: from vessel wall pathology to therapeutic approach
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Intracranial aneurysms: from vessel wall pathology to therapeutic approach
Do you wish to request the book?
Intracranial aneurysms: from vessel wall pathology to therapeutic approach
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Intracranial aneurysms: from vessel wall pathology to therapeutic approach
2011
Overview
Intracranial arterial aneurysms can pose life-threatening risks to patients, so understanding the cause and the progression of these lesions is important for choosing the right treatment. This Review argues that aneurysms are a symptom of an underlying vascular disease rather than constituting a disease on their own. The authors classify intracranial aneurysms by vessel wall pathology and demonstrate that knowledge of the morphology and pathology of this structure is important in determining the therapeutic approach.
An aneurysm is a focal dilatation of an arterial blood vessel. Luminal forces, such as high blood flow, shear stress and turbulence, are implicated in the pathogenesis of intracranial aneurysms, and luminal characteristics, such as sac size and morphology, are usually essential to the clinical decision-making process. Despite frequent clinical emphasis on the vessel lumen, however, the pathology underlying the formation, growth and rupture of an aneurysm mainly resides in the vessel wall. Research on the morphology and histopathology of the vessel wall reveals that intracranial aneurysms do not constitute a single disease, but are a shared manifestation of a wide range of diseases, each of which has a unique natural history and optimum therapy. This Review classifies intracranial aneurysms by vessel wall pathology, and demonstrates that understanding the morphology and pathology of this structure is important in determining the therapeutic approach. The article concludes that aneurysms represent a symptom of an underlying vascular disease rather than constituting a disease on their own.
Key Points
Intracranial aneurysms do not constitute a single disease, but are a manifestation of a wide range of diseases
Aneurysmal diseases vary in their natural histories and optimum treatment strategies
Despite frequent clinical emphasis on the vessel lumen, the pathology underlying aneurysm formation, growth and rupture mainly resides in the vessel wall
A classification of intracranial aneurysms based on vessel wall pathology is important to understand these life-threatening conditions and to determine the best therapeutic approaches
Publisher
Nature Publishing Group UK,Nature Publishing Group
