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Canonical Wnt Signaling Negatively Regulates Platelet Function
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Journal Article
Canonical Wnt Signaling Negatively Regulates Platelet Function
2009
Overview
Wnts regulate important intracellular signaling events, and dysregulation of the Wnt pathway has been linked to human disease. Here, we uncover numerous Wnt canonical effectors in human platelets where Wnts, their receptors, and downstream signaling components have not been previously described. We demonstrate that the Wnt3a ligand inhibits platelet adhesion, activation, dense granule secretion, and aggregation. Wnt3a also altered platelet shape change and inhibited the activation of the small GTPase RhoA. In addition, we found the Wnt-β-catenin signaling pathway to be functional in platelets. Finally, disruption of the Wnt Frizzled 6 receptor in the mouse resulted in a hyperactivatory platelet phenotype and a reduced sensitivity to Wnt3a. Taken together our studies reveal a novel functional role for Wnt signaling in regulating anucleate platelet function and may provide a tractable target for future antiplatelet therapy.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Agonists
/ Animals
/ Blood Platelets - metabolism
/ Disease
/ Frizzled Receptors - metabolism
/ Genetics
/ Humans
/ Ligands
/ Mice
/ Platelet Adhesiveness - physiology
/ Platelet Glycoprotein GPIIb-IIIa Complex - metabolism
/ Receptors, G-Protein-Coupled - metabolism
/ rhoA GTP-Binding Protein - metabolism
/ Rodents
/ Secretory Vesicles - metabolism
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