Asset Details
Do you wish to reserve the book?
Itraconazole to Prevent Fungal Infections in Chronic Granulomatous Disease
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Itraconazole to Prevent Fungal Infections in Chronic Granulomatous Disease
Do you wish to request the book?
Itraconazole to Prevent Fungal Infections in Chronic Granulomatous Disease
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Itraconazole to Prevent Fungal Infections in Chronic Granulomatous Disease
2003
Overview
In chronic granulomatous disease of childhood, killing of microorganisms is impaired because of defects in the production of hydrogen peroxide. In this controlled study, 39 patients were treated in alternate years with either itraconazole or placebo, once per day. There were seven serious infections during treatment with placebo, and only one during treatment with itraconazole.
Chronic granulomatous disease of childhood is a rare group of inherited disorders of phagocytic cells characterized clinically by recurrent life-threatening infections and excessive granuloma formation.
1
Phagocyte migration and phagocytosis are normal, but killing of microorganisms is impaired because of defective production of hydrogen peroxide and related products of oxygen metabolism. A variety of biochemical defects lead to the disorder.
The current mortality rate is 2 to 5 percent per year.
2
In the absence of prophylaxis with antibiotics or interferon gamma, patients with chronic granulomatous disease have severe infections due to catalase-positive bacteria and fungi about once a year. Prophylaxis with . . .
Publisher
Massachusetts Medical Society
Subject
/ Adult
/ Antibiotics. Antiinfectious agents. Antiparasitic agents
/ Antifungal Agents - adverse effects
/ Antifungal Agents - therapeutic use
/ Biological and medical sciences
/ Child
/ Female
/ Granulomatous Disease, Chronic - complications
/ Granulomatous Disease, Chronic - drug therapy
/ Humans
/ Immunodeficiencies. Immunoglobulinopathies
/ Itraconazole - adverse effects
/ Itraconazole - therapeutic use
/ Male
/ Mycoses - prevention & control
/ Pharmacology. Drug treatments
