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Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects

by Korczyn, Amos D. , Di Donato, Ilaria , Duering, Marco , Malandrini, Alessandro , Bianchi, Silvia , Federico, Antonio , Rufa, Alessandra , Dotti, Maria Teresa , Pantoni, Leonardo , Dichgans, Martin , Sinanović, Osman , Jouvent, Eric , Stojanov, Dragan , Penco, Silvana , De Stefano, Nicola , Lesnik-Oberstein, Saskia A. J. , Markus, Hugh S.

in Apathy / Biomedicine / CADASIL - complications / Cerebral Small Vessel Diseases - etiology / Cerebral Small Vessel Diseases - pathology / Cognitive ability / Dementia / Diagnosis / Disease / Dysarthria / Emotional disorders / Genetic aspects / Humans / Hypertension / Ischemia / Leukoencephalopathy / Medicine / Medicine & Public Health / Memory / Mental depression / Migraine / Mood disorders / Mutation / Patients / Review / Stroke / Vascular Dementia

2017

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Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects

2017

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Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects

2017

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Journal Article

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects

Korczyn, Amos D.,

Di Donato, Ilaria,

Duering, Marco,

Malandrini, Alessandro,

Bianchi, Silvia,

Federico, Antonio,

Rufa, Alessandra,

Dotti, Maria Teresa,

Pantoni, Leonardo,

Dichgans, Martin,

Sinanović, Osman,

Jouvent, Eric,

Stojanov, Dragan,

Penco, Silvana,

De Stefano, Nicola,

Lesnik-Oberstein, Saskia A. J.,

Markus, Hugh S.

2017

Overview

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common and best known monogenic small vessel disease. Here, we review the clinical, neuroimaging, neuropathological, genetic, and therapeutic aspects based on the most relevant articles published between 1994 and 2016 and on the personal experience of the authors, all directly involved in CADASIL research and care. We conclude with some suggestions that may help in the clinical practice and management of these patients.

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Publisher

BioMed Central,BioMed Central Ltd,Springer Nature B.V

Subject

Apathy

/ Biomedicine

/ CADASIL - complications

/ Cerebral Small Vessel Diseases - etiology

/ Cerebral Small Vessel Diseases - pathology

/ Cognitive ability

/ Dementia