Journal Article

Lung cancer survival by immigrant status: a population-based retrospective cohort study in Ontario, Canada

Ruco, Arlinda, Lu, Hong, Kopp, Alexander, Lofters, Aisha K., Guilcher, Sara, Datta, Geetanjali D., Vahabi, Mandana, Baxter, Nancy N.

2024

Overview

Background Lung cancer is one of the most common cancers and causes of cancer death in Canada. Some previous literature suggests that socioeconomic inequalities in lung cancer screening, treatment and survival may exist. The objective of this study was to compare overall survival for immigrants versus long-term residents of Ontario, Canada among patients diagnosed with lung cancer. Methods This population-based retrospective cohort study utilized linked health administrative databases and identified all individuals (immigrants and long-term residents) aged 40 + years diagnosed with incident lung cancer between April 1, 2012 and March 31, 2017. The primary outcome was 5-year overall survival with December 31, 2019 as the end of the follow-up period. We implemented adjusted Cox proportional hazards models stratified by age at diagnosis, sex, and cancer stage at diagnosis to examine survival. Results Thirty-eight thousand seven hundred eighty-eight individuals diagnosed with lung cancer were included in our cohort including 7% who were immigrants. Immigrants were younger at diagnosis and were more likely to reside in the lowest neighbourhood income quintile (30.6% versus 24.5%) than long-term residents. After adjusting for age at diagnosis, neighbourhood income quintile, comorbidities, visits to primary care in the 6 to 30 months before diagnosis, continuity of care, cancer type and cancer stage at diagnosis, immigrant status was associated with a lower hazard of dying 5-years post-diagnosis for both females (0.7; 95% CI 0.6–0.8) and males (0.7; 95% CI 0.6–0.7) in comparison to long-term residents. This trend held in adjusted models stratified by cancer stage at diagnosis. For example, female immigrants diagnosed with early stage lung cancer had a hazard ratio of 0.5 (95% CI 0.4–0.7) in comparison to long-term residents. Conclusion Overall survival post diagnosis with lung cancer was better among Ontario immigrants versus long-term residents. Additional research, potentially on the protective effects of immigrant enclave and the intersection of immigrant status with racial/ethnic identity, is needed to further explore why better overall survival for immigrants remained.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adult / Aged / Aged, 80 and over / Analysis / Biomedical and Life Sciences / Biomedicine / Cancer / Cancer Research / Cancer screening / Care and treatment / Comorbidity / Demographic aspects / Development and progression / Diagnosis / Economic aspects / Emigrants and Immigrants - statistics & numerical data / Female / Health aspects / Health care disparities / Health Promotion and Disease Prevention / Humans / Immigrants / Lung cancer / Lung Neoplasms - epidemiology / Lung Neoplasms - ethnology / Lung Neoplasms - mortality / Lung Neoplasms - pathology / Male / Medicine/Public Health / Middle Aged / Mortality / Oncology / Oncology, Experimental / Ontario - epidemiology / Population studies / Primary care / Proportional Hazards Models / Retrospective cohort study / Retrospective Studies / Social aspects / Socioeconomic Factors / Surgical Oncology / Survival