Asset Details
Do you wish to reserve the book?
Beyond plasticity: the dynamic impact of electrical synapses on neural circuits
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Beyond plasticity: the dynamic impact of electrical synapses on neural circuits
Do you wish to request the book?
Beyond plasticity: the dynamic impact of electrical synapses on neural circuits
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Beyond plasticity: the dynamic impact of electrical synapses on neural circuits
2019
Overview
Electrical synapses are found in vertebrate and invertebrate nervous systems. The cellular basis of these synapses is the gap junction, a group of intercellular channels that mediate direct communication between adjacent neurons. Similar to chemical synapses, electrical connections are modifiable and their variations in strength provide a mechanism for reconfiguring neural circuits. In addition, electrical synapses dynamically regulate neural circuits through properties without equivalence in chemical transmission. Because of their continuous nature and bidirectionality, electrical synapses allow electrical currents underlying changes in membrane potential to leak to ‘coupled’ partners, dampening neuronal excitability and altering their integrative properties. Remarkably, this effect can be transiently alleviated when comparable changes in membrane potential simultaneously occur in each of the coupled neurons, a phenomenon that is dynamically dictated by the timing of arriving signals such as synaptic potentials. By way of this mechanism, electrical synapses influence synaptic integration and action potential generation, imparting an additional layer of dynamic complexity to neural circuits.Electrical synapses comprise intercellular channels termed gap junctions and are found in vertebrate and invertebrate nervous systems. In this Review, Pepe Alcamí and Alberto Pereda examine the properties of electrical synapses that influence neural circuit dynamics without modifying gap junction conductance.
Publisher
Nature Publishing Group
Subject
