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Long noncoding RNAs regulate adipogenesis

by Alexander, Ryan , Hacisuleyman, Ezgi , Sauvageau, Martin , Hendrickson, David G. , Kelley, David R. , Yuan, Bingbing , Kellis, Manolis , Tazon-Vega, Barbara , Rinn, John L. , Sun, Lei , Lo, Kinyui Alice , Trapnell, Cole , Lodish, Harvey F. , Goff, Loyal A.

in Adipocytes / adipogenesis / Adipogenesis - genetics / Animals / Binding sites / Biological Sciences / Brown adipocytes / Cell Biology / Cell culture / Cell lines / Gene Expression Profiling / Gene Expression Regulation / Gene Knockdown Techniques / Genes / Information Theory / Lipogenesis / Male / messenger RNA / Mice / microRNA / non-coding RNA / obesity / Oligonucleotide Array Sequence Analysis / Open Reading Frames - genetics / Phenotype / Pluripotent stem cells / Proteins / Reproducibility of Results / Ribonucleic acid / RNA / RNA, Long Noncoding - genetics / RNA, Long Noncoding - metabolism / Small interfering RNA / T cell receptors / transcription factors / transcriptome / Transcriptome - genetics / White adipocytes

2013

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2013

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2013

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Journal Article

Long noncoding RNAs regulate adipogenesis

Alexander, Ryan,

Hacisuleyman, Ezgi,

Sauvageau, Martin,

Hendrickson, David G.,

Kelley, David R.,

Yuan, Bingbing,

Kellis, Manolis,

Tazon-Vega, Barbara,

Rinn, John L.,

Sun, Lei,

Lo, Kinyui Alice,

Trapnell, Cole,

Lodish, Harvey F.,

Goff, Loyal A.

2013

Overview

The prevalence of obesity has led to a surge of interest in understanding the detailed mechanisms underlying adipocyte development. Many protein-coding genes, mRNAs, and microRNAs have been implicated in adipocyte development, but the global expression patterns and functional contributions of long noncoding RNA (lncRNA) during adipogenesis have not been explored. Here we profiled the transcriptome of primary brown and white adipocytes, preadipocytes, and cultured adipocytes and identified 175 lncRNAs that are specifically regulated during adipogenesis. Many lncRNAs are adipose-enriched, strongly induced during adipogenesis, and bound at their promoters by key transcription factors such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (CEBPα). RNAi-mediated loss of function screens identified functional lncRNAs with varying impact on adipogenesis. Collectively, we have identified numerous lncRNAs that are functionally required for proper adipogenesis.

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Publisher

National Academy of Sciences

Subject

Adipocytes

/ adipogenesis

/ Adipogenesis - genetics

/ Animals

/ Binding sites

/ Biological Sciences

/ Brown adipocytes