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Mechanism of acute tryptophan depletion: is it only serotonin?

by Kelly, P A T , van Donkelaar, E L , Blokland, A , Ferrington, L , Prickaerts, J , Steinbusch, H W M

in 631/378/340 / 631/378/548/1964 / 692/699/476 / Adult and adolescent clinical studies / Amino acids / Animals / Behavioral Sciences / Biological and medical sciences / Biological Psychology / Brain - metabolism / Brain research / Brain-Derived Neurotrophic Factor - metabolism / Cerebrovascular Disorders - etiology / Cerebrovascular Disorders - metabolism / Cognition - physiology / Cognition disorders / Cognitive ability / Depression / Development and progression / Eating - genetics / feature-review / Genetic aspects / Human subjects / Humans / Kynurenine - metabolism / Laboratory animals / Life sciences / Medical sciences / Medicine / Medicine & Public Health / Mental depression / Mental disorders / Mental Disorders - etiology / Mental Disorders - metabolism / Mental health / Metabolism / Models, Biological / Mood disorders / Neuropsychology / Neurosciences / Neurotransmission / Pharmacotherapy / Physiological aspects / Physiology / Plasma / Psychiatry / Psychology. Psychoanalysis. Psychiatry / Psychopathology. Psychiatry / Risk factors / Serotonin / Serotonin - metabolism / Tryptophan / Tryptophan - deficiency

2011

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Mechanism of acute tryptophan depletion: is it only serotonin?

by Kelly, P A T , van Donkelaar, E L , Blokland, A , Ferrington, L , Prickaerts, J , Steinbusch, H W M

2011

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Mechanism of acute tryptophan depletion: is it only serotonin?

by Kelly, P A T , van Donkelaar, E L , Blokland, A , Ferrington, L , Prickaerts, J , Steinbusch, H W M

2011

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Journal Article

Mechanism of acute tryptophan depletion: is it only serotonin?

Kelly, P A T,

van Donkelaar, E L,

Blokland, A,

Ferrington, L,

Prickaerts, J,

Steinbusch, H W M

2011

Overview

The method of acute tryptophan depletion (ATD), which reduces the availability of the essential amino acid tryptophan (TRP), the dietary serotonin (5-hydroxytryptamine (5-HT)) precursor, has been applied in many experimental studies. ATD application leads to decreased availability of TRP in the brain and its synthesis into 5-HT. It is therefore assumed that a decrease in 5-HT release and subsequent blunted neurotransmission is the underlying mechanism for the behavioural effects of ATD. However, direct evidence that ATD decreases extracellular 5-HT concentrations is lacking. Furthermore, several studies provide support for alternative underlying mechanisms of ATD. This may question the utility of the method as a selective serotonergic challenge tool. As ATD is extensively used for investigating the role of 5-HT in cognitive functions and psychiatric disorders, the potential of alternative mechanisms and possible confounding factors should be taken into account. It is suggested that caution is required when interpreting ATD effects in terms of a selective serotonergic effect.

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Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

631/378/340

/ 631/378/548/1964

/ 692/699/476

/ Adult and adolescent clinical studies

/ Amino acids

/ Animals

/ Behavioral Sciences