Asset Details
Do you wish to reserve the book?
The CatSper channel: a polymodal chemosensor in human sperm
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The CatSper channel: a polymodal chemosensor in human sperm
Do you wish to request the book?
The CatSper channel: a polymodal chemosensor in human sperm
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The CatSper channel: a polymodal chemosensor in human sperm
2012
Overview
The sperm‐specific CatSper channel controls the intracellular Ca
2+
concentration ([Ca
2+
]
i
) and, thereby, the swimming behaviour of sperm. In humans, CatSper is directly activated by progesterone and prostaglandins—female factors that stimulate Ca
2+
influx. Other factors including neurotransmitters, chemokines, and odorants also affect sperm function by changing [Ca
2+
]
i
. Several ligands, notably odorants, have been proposed to control Ca
2+
entry and motility via G protein‐coupled receptors (GPCRs) and cAMP‐signalling pathways. Here, we show that odorants directly activate CatSper without involving GPCRs and cAMP. Moreover, membrane‐permeable analogues of cyclic nucleotides that have been frequently used to study cAMP‐mediated Ca
2+
signalling also activate CatSper directly via an extracellular site. Thus, CatSper or associated protein(s) harbour promiscuous binding sites that can host various ligands. These results contest current concepts of Ca
2+
signalling by GPCR and cAMP in mammalian sperm: ligands thought to activate metabotropic pathways, in fact, act via a common ionotropic mechanism. We propose that the CatSper channel complex serves as a polymodal sensor for multiple chemical cues that assist sperm during their voyage across the female genital tract.
The calcium channel CatSper governs sperm swimming behaviour in response to progesterone and prostaglandins. Surprisingly, multiple types of small molecules including odorants and nucleotides directly activate CatSper‐mediated calcium influx independent of G protein‐coupled receptor (GPCR) or cAMP signalling.
Publisher
John Wiley & Sons, Ltd,Nature Publishing Group UK,Springer Nature B.V,Nature Publishing Group
Subject
/ Benzimidazoles - pharmacology
/ Calcium Channel Blockers - pharmacology
/ Calcium Channels - metabolism
/ Calcium Signaling - drug effects
/ Calcium Signaling - physiology
/ Cyclopropanes - pharmacology
/ EMBO20
/ EMBO37
/ Humans
/ Male
/ Mammals
/ odorants
/ Proteins
/ Receptors, G-Protein-Coupled - metabolism
/ Sperm
