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Randomized Trial of Lifestyle Modification and Pharmacotherapy for Obesity
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Randomized Trial of Lifestyle Modification and Pharmacotherapy for Obesity
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Journal Article
Randomized Trial of Lifestyle Modification and Pharmacotherapy for Obesity
2005
Overview
In this randomized, controlled trial, 224 obese adults were assigned to one of four weight-loss treatments for one year: sibutramine alone, lifestyle modification through group therapy alone, combined therapy, or sibutramine plus brief counseling about lifestyle modification delivered by a physician. Combined therapy resulted in more weight loss than either drug therapy alone or lifestyle modification alone, underscoring the importance of prescribing weight-loss medications in combination with, rather than in lieu of, lifestyle modification.
Combined therapy resulted in more weight loss than either drug therapy alone or lifestyle modification alone, underscoring the importance of prescribing weight-loss medications in combination with, rather than in lieu of, lifestyle modification
Two medications, sibutramine (Meridia, Abbott Laboratories) and orlistat (Xenical, Roche), are currently approved by the Food and Drug Administration for the induction and maintenance of weight loss.
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These agents are recommended as an adjunct to a comprehensive program of diet, exercise, and behavior therapy,
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which is known as lifestyle modification and is delivered in weekly group or individual sessions.
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Industry-sponsored trials of weight-loss medications typically have included limited programs of lifestyle modification.
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This randomized trial compared the efficacy of sibutramine alone (as typically prescribed in primary care practice), group sessions of lifestyle modification alone, . . .
Publisher
Massachusetts Medical Society
