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Relationship between diffusion capacity and small airway abnormality in COPDGene
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Relationship between diffusion capacity and small airway abnormality in COPDGene
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Journal Article
Relationship between diffusion capacity and small airway abnormality in COPDGene
2019
Overview
Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is undescribed. We hypothesized that in mild COPD, functional SAD (fSAD) defined by computed tomography (CT) and Parametric Response Mapping methodology would correlate with impaired DLCO. Using data from ever-smokers in the COPDGene cohort, we established that fSAD correlated significantly with lower DLCO among both non-obstructed and GOLD 1–2 subjects. The relationship between DLCO with CT-defined emphysema was present in all GOLD stages, but most prominent in severe disease.
Trial registration
NCT00608764
. Registry: COPDGene. Registered 06 February 2008, retrospectively registered.
Publisher
BioMed Central,BioMed Central Ltd,Nature Publishing Group,BMC
Subject
/ Airway Obstruction - diagnostic imaging
/ Airway Obstruction - pathology
/ Airway Remodeling - physiology
/ Carbon Monoxide - metabolism
/ Chronic obstructive lung disease
/ Chronic obstructive pulmonary disease
/ Chronic obstructive pulmonary disease (COPD)
/ Diffusing capacity of the lung (DLCO)
/ Female
/ Gold
/ Humans
/ Lungs
/ Male
/ Mapping
/ Medicine
/ Parametric response mapping (PRM)
/ Pneumology/Respiratory System
/ Pulmonary Diffusing Capacity
/ Pulmonary Disease, Chronic Obstructive - diagnostic imaging
/ Pulmonary Disease, Chronic Obstructive - genetics
/ Pulmonary Emphysema - diagnostic imaging
/ Pulmonary Emphysema - genetics
/ Smokers
