Asset Details
Do you wish to reserve the book?
The chromatin remodeler LET-418/Mi-2 regulates the intracellular pathogen response in the C. elegans intestine
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The chromatin remodeler LET-418/Mi-2 regulates the intracellular pathogen response in the C. elegans intestine
Do you wish to request the book?
The chromatin remodeler LET-418/Mi-2 regulates the intracellular pathogen response in the C. elegans intestine
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The chromatin remodeler LET-418/Mi-2 regulates the intracellular pathogen response in the C. elegans intestine
2025
Overview
Chromatin remodeling provides essential transcriptional regulation for all biological processes. In
Caenorhabditis elegans
, the chromatin remodeler LET-418, a homolog of the human Mi-2β protein, plays a critical role in regulating development, organogenesis, tissue maintenance, stress resistance and lifespan. LET-418 is part of several chromatin remodeling complexes and contributes significantly to the balance between growth and defense mechanisms, yet its target genes remain unclear. Using DNA methylation profiling, we identified genomic binding sites and associated target genes of LET-418 and its MEC-complex-specific interactor MEP-1 in the intestine. Consistent with their presence in the same complex, the two proteins shared more than half of their target genes. Functional analysis revealed that LET-418 and MEP-1 target genes are highly active in the intestine and are involved in repressing innate immune responses, including the intracellular pathogen response (IPR). Consistently, in
let-418
mutants, IPR-induced genes, such as
pals-5
or
pals-2
are strongly upregulated, in a manner dependent on ZIP-1, a major transcription factor for IPR. Additionally, we found pathogen levels of the natural intracellular intestinal pathogen
Nematocida parisii
significantly reduced in
let-418
mutants, supporting the observation of increased IPR in this mutant. Altogether, these findings reveal a crucial role for LET-418 as a modulator of the IPR, aligning with its role in maintaining the balance between development and defense.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Animal Genetics and Genomics
/ Animals
/ Biomedical and Life Sciences
/ Caenorhabditis elegans - genetics
/ Caenorhabditis elegans - immunology
/ Caenorhabditis elegans - metabolism
/ Caenorhabditis elegans - microbiology
/ Caenorhabditis elegans Proteins - genetics
/ Caenorhabditis elegans Proteins - metabolism
/ Chromatin Assembly and Disassembly
/ Control
/ Genes
/ Genomes
/ Identification and classification
/ Intestinal Mucosa - metabolism
/ Microbial Genetics and Genomics
/ Mutants
/ Mutation
/ Proteins
/ Transcription Factors - genetics
