Asset Details
Do you wish to reserve the book?
B‐DNA Structure and Stability: The Role of Nucleotide Composition and Order
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
B‐DNA Structure and Stability: The Role of Nucleotide Composition and Order
Do you wish to request the book?
B‐DNA Structure and Stability: The Role of Nucleotide Composition and Order
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
B‐DNA Structure and Stability: The Role of Nucleotide Composition and Order
2022
Overview
We have quantum chemically analyzed the influence of nucleotide composition and sequence (that is, order) on the stability of double‐stranded B‐DNA triplets in aqueous solution. To this end, we have investigated the structure and bonding of all 32 possible DNA duplexes with Watson–Crick base pairing, using dispersion‐corrected DFT at the BLYP‐D3(BJ)/TZ2P level and COSMO for simulating aqueous solvation. We find enhanced stabilities for duplexes possessing a higher GC base pair content. Our activation strain analyses unexpectedly identify the loss of stacking interactions within individual strands as a destabilizing factor in the duplex formation, in addition to the better‐known effects of partial desolvation. Furthermore, we show that the sequence‐dependent differences in the interaction energy for duplexes of the same overall base pair composition result from the so‐called “diagonal interactions” or “cross terms”. Whether cross terms are stabilizing or destabilizing depends on the nature of the electrostatic interaction between polar functional groups in the pertinent nucleobases. All about that sequence! Quantum chemical analyses reveal that the stability of B‐DNA triplets depends not only on the nucleotide composition, but also on the order in which the nucleotides occur. This sequence dependence in the duplex stability results primarily from attractive or repulsive cross terms between bases in adjacent Watson–Crick pairs.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley-VCH
Subject
We currently cannot retrieve any items related to this title. Kindly check back at a later time.