Journal Article

Inflammatory-Related Clinical and Metabolic Outcomes in COVID-19 Patients

Rosado, Silvia, Martinez-Urbistondo, Maria, Castejón, Raquel, Mora-Vargas, Alberto, Fernández-Cruz, Ana, Citores, M. Jesús, Daimiel, Lidia, Martínez, J. Alfredo, Vargas, Juan A., Baños, Isolina, Expósito-Palomo, Esther, San-Cristóbal, Rodrigo, de Mendoza, Carmen

2020

Overview

Background. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) infection elicits inflammatory manifestations that relate with a “cytokine storm.” Objective. The aim of this research was to assess the role of circulating interleukin 6 (IL-6) levels and other inflammatory markers in patients with coronavirus disease 2019 (COVID-19) on metabolic functions and accompanying clinical complications. Patients and Methods. A total of 165 patients diagnosed with COVID-19 pneumonia were examined for medical features and inflammatory markers such as blood IL-6, CRP, ferritin, LDH, neutrophil/lymphocyte index (NLI), D-Dimer, and Red Cell Distribution Width (RDW). Regression analyses concerning electronically collected medical data were adjusted by appropriate factors and confounding variables. Results. Plasma IL-6 determinations evidenced a consistent association with hospital stay days, Intensive Care Unit (ICU) admission, and mortality rates. Similar trends were found for other proinflammatory variables, where ferritin and NLI showed a remarkable value as surrogates. Hyperglycaemia and the Charlson Comorbidity Index Score were positively associated with the inflammatory response induced by the SARS-COV-2 infection. An unhealthy lifestyle such as smoking and alcoholic drinks consumption as well as excessive body adiposity influenced inflammatory-related outcomes in the screened patients. Conclusion. IL-6 together with other inflammatory biomarkers accompanied poor clinical and metabolic outcomes in COVID-19-infected patients. IL-6 may result in a suitable proxy to individually categorise patients in order to manage this infectious pandemic.

• Publisher: Hindawi Publishing Corporation,Hindawi,John Wiley & Sons, Inc,Wiley
• Subject: Adipose tissue / Aged / Alcoholic beverages / Blood pressure / Body mass index / C-Reactive Protein - analysis / Comorbidity / Coronaviruses / COVID-19 / COVID-19 - complications / COVID-19 - immunology / COVID-19 - metabolism / Cross-Sectional Studies / Cytokine storm / Data collection / Dehydrogenases / Diabetes / Disease transmission / Female / Ferritin / Glucose / Humans / Hyperglycemia / Hypertension / Immune system / Inflammation / Inflammation - etiology / Interleukin 6 / Interleukin-6 - blood / Interleukins / Lymphocytes / Male / Metabolism / Middle Aged / Mortality / Neutrophils / Pandemics / Patient outcomes / Patients / Pneumonia / Proteins / Retrospective Studies / SARS-CoV-2 / Severe acute respiratory syndrome / Severe acute respiratory syndrome coronavirus 2 / Standard deviation / Variance analysis