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qSOFA combined with suPAR for early risk detection and guidance of antibiotic treatment in emergency department: a bit sweet and a bit sour randomized controlled trial
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qSOFA combined with suPAR for early risk detection and guidance of antibiotic treatment in emergency department: a bit sweet and a bit sour randomized controlled trial
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qSOFA combined with suPAR for early risk detection and guidance of antibiotic treatment in emergency department: a bit sweet and a bit sour randomized controlled trial
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Journal Article
qSOFA combined with suPAR for early risk detection and guidance of antibiotic treatment in emergency department: a bit sweet and a bit sour randomized controlled trial
2024
Overview
[...]the focus of study was qSOFA but in first part of the study recruitment of subjects was based on two signs of SIRS (Systemic inflammatory response syndrome). No two parameters overlap between SIRS criteria (temperature, heart rate, respiratory rate and white blood cell count) and qSOFA parameters (respiratory rate, altered mental status and hypotension). [...]the recruitment likely included patient with only one common factor i.e. the respiratory rate, restricting recruitment to particular subset of patient and hence must have missed suitable patients which could fulfilled inclusion criteria based on blood pressure or neurological parameters. [...]the suPAR cut off values may be reflection of patients with respiratory pathology and likely also be the reason the meropenem group in the SUPERIOR (SUPar-guided doublE-blind randomized controlled trial of Initiation Of antibiotics foR presumed infection at the emergency department) study showed significant advantage compared to placebo, since respiratory cases constituting the majority of recruited patients.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V
Subject
Anti-Bacterial Agents - therapeutic use
/ Emergency Service, Hospital - organization & administration
/ Emergency Service, Hospital - statistics & numerical data
/ Humans
/ Medicine
/ Patients
/ Randomized Controlled Trials as Topic - methods
/ Receptors, Urokinase Plasminogen Activator - analysis
/ Receptors, Urokinase Plasminogen Activator - blood
/ Sepsis
