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Large-scale electron microscopy database for human type 1 diabetes
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Large-scale electron microscopy database for human type 1 diabetes
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Journal Article
Large-scale electron microscopy database for human type 1 diabetes
2020
Overview
Autoimmune β-cell destruction leads to type 1 diabetes, but the pathophysiological mechanisms remain unclear. To help address this void, we created an open-access online repository, unprecedented in its size, composed of large-scale electron microscopy images (‘nanotomy’) of human pancreas tissue obtained from the Network for Pancreatic Organ donors with Diabetes (nPOD;
www.nanotomy.org
). Nanotomy allows analyses of complete donor islets with up to macromolecular resolution. Anomalies we found in type 1 diabetes included (i) an increase of ‘intermediate cells’ containing granules resembling those of exocrine zymogen and endocrine hormone secreting cells; and (ii) elevated presence of innate immune cells. These are our first results of mining the database and support recent findings that suggest that type 1 diabetes includes abnormalities in the exocrine pancreas that may induce endocrine cellular stress as a trigger for autoimmunity.
Type 1 diabetes is associated with autoimmune destruction of pancreatic beta-cells. Here the authors compose a large-scale electron microscopy image data base of pancreatic organ donor tissue to enable data mining and further understanding of the disease.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/63
/ Cytoplasmic Granules - ultrastructure
/ Diabetes
/ Diabetes mellitus (insulin dependent)
/ Diabetes Mellitus, Type 1 - pathology
/ Endoplasmic Reticulum - metabolism
/ Endoplasmic Reticulum - ultrastructure
/ Humanities and Social Sciences
/ Humans
/ Islets of Langerhans - immunology
/ Islets of Langerhans - pathology
/ Islets of Langerhans - ultrastructure
/ Mitochondria - ultrastructure
/ Pancreas
/ Science
