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An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swine
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An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swine
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Journal Article
An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swine
2018
Overview
Porcine epidemic diarrhea virus (PEDV) has catastrophic impacts on the global pig industry. Although the fecal–oral route is generally accepted, an increased number of reports indicate that airborne transmission may contribute to PEDV outbreak. Here, we show that PEDV could cause typical diarrhea in piglets through a nasal spray. Firstly, PEDV can develop a transient nasal epithelium infection. Subsequently, PEDV-carrying dendritic cells (DCs) allow the virus to be transferred to CD3
+
T cells via the virological synapse. Finally, virus-loaded CD3
+
T cells reach the intestine through the blood circulation, leading to intestinal infection via cell-to-cell contact. Our study provides evidence for airborne transmission of a gastrointestinal infected coronavirus and illustrates the mechanism of its transport from the entry site to the pathogenic site.
Outbreaks of porcine epidemic diarrhea virus (PEDV) have seriously affected pig farms around the world. Here, Li et al. show that PEDV can cause disease in piglets when inoculated by nasal spray, and provide insights into the cellular mechanisms underlying PEDV dissemination within the host.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/1
/ 13/106
/ 13/31
/ 14
/ 14/19
/ 14/28
/ 45
/ 82/51
/ 82/80
/ Animals
/ Coronavirus Infections - blood
/ Coronavirus Infections - immunology
/ Coronavirus Infections - pathology
/ Coronavirus Infections - virology
/ Dendritic Cells - metabolism
/ Dendritic Cells - ultrastructure
/ Diarrhea
/ Hogs
/ Humanities and Social Sciences
/ Intestinal Mucosa - pathology
/ Intestinal Mucosa - ultrastructure
/ Intestinal Mucosa - virology
/ Mucosa
/ Nasal Cavity - ultrastructure
/ Nose
/ Porcine epidemic diarrhea virus - physiology
/ Science
/ Swine
/ Synapses
/ T-Lymphocytes - ultrastructure
/ Transmissible gastroenteritis
/ Viruses
