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Clear Cell Sarcoma–like Tumor of the Gastrointestinal Tract: An Evolving Entity
by
Wang, Jayson
, Thway, Khin
in
Development and progression
/ Gastrointestinal Neoplasms - genetics
/ Gastrointestinal Neoplasms - pathology
/ Gastrointestinal system
/ Genetic research
/ Health aspects
/ Humans
/ Metastasis
/ Mortality
/ Sarcoma
/ Sarcoma, Clear Cell - genetics
/ Sarcoma, Clear Cell - pathology
2015
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Clear Cell Sarcoma–like Tumor of the Gastrointestinal Tract: An Evolving Entity
by
Wang, Jayson
, Thway, Khin
in
Development and progression
/ Gastrointestinal Neoplasms - genetics
/ Gastrointestinal Neoplasms - pathology
/ Gastrointestinal system
/ Genetic research
/ Health aspects
/ Humans
/ Metastasis
/ Mortality
/ Sarcoma
/ Sarcoma, Clear Cell - genetics
/ Sarcoma, Clear Cell - pathology
2015
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Do you wish to request the book?
Clear Cell Sarcoma–like Tumor of the Gastrointestinal Tract: An Evolving Entity
by
Wang, Jayson
, Thway, Khin
in
Development and progression
/ Gastrointestinal Neoplasms - genetics
/ Gastrointestinal Neoplasms - pathology
/ Gastrointestinal system
/ Genetic research
/ Health aspects
/ Humans
/ Metastasis
/ Mortality
/ Sarcoma
/ Sarcoma, Clear Cell - genetics
/ Sarcoma, Clear Cell - pathology
2015
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Clear Cell Sarcoma–like Tumor of the Gastrointestinal Tract: An Evolving Entity
Journal Article
Clear Cell Sarcoma–like Tumor of the Gastrointestinal Tract: An Evolving Entity
2015
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Overview
Clear cell sarcoma–like tumor of the gastrointestinal tract (CCSLGT) is a rare malignant neoplasm that occurs in the wall of the small bowel, stomach, or large bowel, predominantly in young adults. It is an aggressive neoplasm that frequently presents with metastatic disease and has a high mortality rate. Histologically, it is usually composed of medium-sized primitive ovoid or epithelioid cells with pale or clear cytoplasm that are arranged in sheets or in papillary or alveolar architectures. Clear cell sarcoma–like tumor of the gastrointestinal tract is positive for S100 protein, invariably negative for melanocyte-specific markers and is often also positive for neuroendocrine markers. The etiology of CCSLGT is unknown, but many studies have shown associations with EWSR1-CREB1 gene fusions and, less frequently, with EWSR1-ATF1 fusions. Here, we discuss the current status of CCSLGT, including histologic, immunophenotypic, and molecular findings.
Publisher
College of American Pathologists
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