Asset Details
Do you wish to reserve the book?
Imine as a linchpin approach for meta-C–H functionalization
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Imine as a linchpin approach for meta-C–H functionalization
Do you wish to request the book?
Imine as a linchpin approach for meta-C–H functionalization
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Imine as a linchpin approach for meta-C–H functionalization
2021
Overview
Despite the widespread applications of C–H functionalization, controlling site selectivity remains a significant challenge. Covalently attached directing groups (DGs) served as ancillary ligands to ensure
ortho
-,
meta
- and
para
-C–H functionalization over the last two decades. These covalently linked DGs necessitate two extra steps for a single C–H functionalization: introduction of DG prior to C–H activation and removal of DG post-functionalization. Here we report a temporary directing group (TDG) for
meta
-C–H functionalization via reversible imine formation. By overruling facile
ortho
-C–H bond activation by imine-
N
atom, a suitably designed pyrimidine-based TDG successfully delivered selective
meta
-C–C bond formation. Application of this temporary directing group strategy for streamlining the synthesis of complex organic molecules without any necessary pre-functionalization at the
meta
position has been explored.
Site-selective C–H functionalization still faces some challenges, such as the introduction and removal of an appropriate directing group. Here, the authors introduce a temporary directing group for selective
meta
-C–H functionalization of 2-arylbenzaldehydes via reversible imine formation.
