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Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps
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Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps
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Journal Article
Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps
2019
Overview
The human pathogen
Helicobacter pylori
displays extensive genetic diversity. While
H. pylori
is known to evolve during infection, population dynamics inside the gastric environment have not been extensively investigated. Here we obtained gastric biopsies from multiple stomach regions of 16
H. pylori
-infected adults, and analyze the genomes of 10
H. pylori
isolates from each biopsy. Phylogenetic analyses suggest location-specific evolution and bacterial migration between gastric regions. Migration is significantly more frequent between the corpus and the fundus than with the antrum, suggesting that physiological differences between antral and oxyntic mucosa contribute to spatial partitioning of
H. pylori
populations. Associations between
H. pylori
gene polymorphisms and stomach niches suggest that chemotaxis, regulatory functions and outer membrane proteins contribute to specific adaptation to the antral and oxyntic mucosa. Moreover, we show that antibiotics can induce severe population bottlenecks and likely play a role in shaping the population structure of
H. pylori
.
Helicobacter pylori
, a bacterial pathogen that infects human stomachs, has high genetic diversity across hosts. Here, Ailloud et al. reveal genetic structuring of
H. pylori
populations among different stomach regions of individual hosts and find signals of genetic associations with stomach region.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/43
/ 631/181
/ 631/326
/ Adaptation, Biological - genetics
/ Adult
/ Aged
/ Biopsy
/ Gastric Mucosa - microbiology
/ Genome, Bacterial - genetics
/ Genomes
/ Helicobacter Infections - microbiology
/ Helicobacter Infections - pathology
/ Helicobacter pylori - genetics
/ Helicobacter pylori - isolation & purification
/ Helicobacter pylori - pathogenicity
/ Humanities and Social Sciences
/ Humans
/ Mucosa
/ Niches
/ Science
/ Stomach
