Asset Details
Do you wish to reserve the book?
Antimicrobial peptide capsids of de novo design
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Antimicrobial peptide capsids of de novo design
Do you wish to request the book?
Antimicrobial peptide capsids of de novo design
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Antimicrobial peptide capsids of de novo design
2017
Overview
The spread of bacterial resistance to antibiotics poses the need for antimicrobial discovery. With traditional search paradigms being exhausted, approaches that are altogether different from antibiotics may offer promising and creative solutions. Here, we introduce a de novo peptide topology that—by emulating the virus architecture—assembles into discrete antimicrobial capsids. Using the combination of high-resolution and real-time imaging, we demonstrate that these artificial capsids assemble as 20-nm hollow shells that attack bacterial membranes and upon landing on phospholipid bilayers instantaneously (seconds) convert into rapidly expanding pores causing membrane lysis (minutes). The designed capsids show broad antimicrobial activities, thus executing one primary function—they destroy bacteria on contact.
With the growing threat of antibiotic resistance, unconventional approaches to antimicrobial discovery are needed. Here, the authors present a peptide topology that mimics virus architecture and assembles into antimicrobial capsids that disrupt bacterial membranes upon contact.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/19
/ 14/3
/ Anti-Infective Agents - chemical synthesis
/ Anti-Infective Agents - metabolism
/ Anti-Infective Agents - pharmacology
/ Antiinfectives and antibacterials
/ Antimicrobial Cationic Peptides - chemical synthesis
/ Antimicrobial Cationic Peptides - metabolism
/ Antimicrobial Cationic Peptides - pharmacology
/ Bacteria
/ Capsids
/ Chemistry Techniques, Synthetic - methods
/ Chromatography, High Pressure Liquid
/ Humanities and Social Sciences
/ Humans
/ Lysis
/ Microscopy, Electron, Transmission
/ Science
/ Shells
/ Topology
/ Viruses
